產品詳情
簡單介紹：
Anti-DERL3 antibody (STJ193127)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Derlin-3 is suitable for use in Western Blot and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DERL3 |
| Gene ID: | 91319 |
| Uniprot ID: | DERL3_HUMAN |
| Specificity: | DERL3 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from part of the human protein |
| Function | Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocations of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded glycoproteins. May be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocations of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. |
| Protein Name | Derlin-3 Degradation In Endoplasmic Reticulum Protein 3 Dertrin-3 Der1-Like Protein 3 |
| Database Links | Reactome: R-HSA-382556 Reactome: R-HSA-5678895 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Derlin-3 antibody Anti-Degradation In Endoplasmic Reticulum Protein 3 antibody Anti-Dertrin-3 antibody Anti-Der1-Like Protein 3 antibody Anti-DERL3 antibody Anti-C22orf14 antibody Anti-DER3 antibody Anti-LLN2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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