Anti-DGCR8 antibody (436-764) [S7MR] (STJ11101977) STJ11101977|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-DGCR8 antibody (436-764) [S7MR] (STJ11101977)
產品型號：STJ11101977
產品廠商：ST john's laboratory
產品文檔：

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簡單介紹：

Anti-DGCR8 antibody (436-764) [S7MR] (STJ11101977)

詳情介紹：

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-DGCR8 (436-764) is suitable for use in Western Blot research applications.

Clonality:	Monoclonal
Clone ID:	S7MR
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	DGCR8
Gene ID:	54487
Uniprot ID:	DGCR8_HUMAN
Immunogen Region:	436-764
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 436-764 of human DGCR8 (Q8WYQ5).
Immunogen Sequence:	DLEEFRSYLEKRFDFEQVTV KKFRTWAERRQFNREMKRKQ AESERPILPANQKLITLSVQ DAPTKKEFVINPNGKSEVCI LHEYMQRVLKVRPVYNFFEC ENPSEPFGASVTIDGVTYGS GTASSKKLAKNKAARATLEI LIPDFVKQTSEEKPKDSEEL EYFNHISIEDSRVYELTSKA GLLSPYQILHECLKRNHGMG DTSIKFEVVPGKNQKSEYVM ACGKHTVRGWCKNKRVGKQ

Tissue Specificity	Ubiquitously expressed.
Function	Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding. Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing. Involved in the silencing of embryonic stem cell self-renewal.
Protein Name	Microprocessor Complex Subunit Dgcr8 Digeorge Syndrome Critical Region 8
Database Links	Reactome: R-HSA-203927 Reactome: R-HSA-8986944
Cellular Localisation	Nucleus Nucleolus Colocalizes With Nucleolin And Drosha In The Nucleolus Mostly Detected In The Nucleolus As Electron-Dense Granular Patches Around The Fibrillar Center (Fc) And Granular Component (Gc) Also Detected In The Nucleoplasm As Small Foci Adjacent To Splicing Speckles Near The Chromatin Structure Localized With Drosha In Gw Bodies (Gwbs) Also Known As P-Bodies
Alternative Antibody Names	Anti-Microprocessor Complex Subunit Dgcr8 antibody Anti-Digeorge Syndrome Critical Region 8 antibody Anti-DGCR8 antibody Anti-C22orf12 antibody Anti-DGCRK6 antibody Anti-LP4941 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-DGCR8 antibody (436-764) [S7MR] (STJ11101977)