產品詳情
簡單介紹：
Anti-DGKZ antibody (601-650 aa) (STJ92700)
詳情介紹：
| Host: | Rabbit |
| Applications: | IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Diacylglycerol kinase zeta (601-650 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC 1:100-1:300 ELISA 1:20000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DGKZ |
| Gene ID: | 8525 |
| Uniprot ID: | DGKZ_HUMAN |
| Immunogen Region: | 601-650 aa |
| Specificity: | DGK-Zeta Polyclonal Antibody detects endogenous levels of DGK-Zeta protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human DGKZ at the amino acid range 601-650 |
| Post Translational Modifications | Phosphorylation of the MARCKS homology domain by PKC reduces nuclear accumulation of DGK-zeta. |
| Function | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosesynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group. The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol. By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization. Through the same mechanism could also positively regulate insulin-induced translocations of SLC2A4 to the cell membrane. Isoform 1: Regulates RASGRP1 activity. Isoform 2: Does not regulate RASGRP1 activity. |
| Protein Name | Diacylglycerol Kinase Zeta Dag Kinase Zeta Diglyceride Kinase Zeta Dgk-Zeta |
| Database Links | Reactome: R-HSA-114508 |
| Cellular Localisation | Nucleus Cytoplasm Cytosol Cell Membrane Cell Projection Lamellipodsium |
| Alternative Antibody Names | Anti-Diacylglycerol Kinase Zeta antibody Anti-Dag Kinase Zeta antibody Anti-Diglyceride Kinase Zeta antibody Anti-Dgk-Zeta antibody Anti-DGKZ antibody Anti-DAGK6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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