產品詳情
簡單介紹：
Anti-DKC1 antibody (245-514) (STJ23384)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/IHC/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-DKC1 (245-514) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DKC1 |
| Gene ID: | 1736 |
| Uniprot ID: | DKC1_HUMAN |
| Immunogen Region: | 245-514 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 245-514 of human DKC1 (NP_001354.1). |
| Immunogen Sequence: | ELRRVRSGVMSEKDHMVTMH DVLDAQWLYDNHKDESYLRR VVYPLEKLLTSHKRLVMKDS AVNAICYGAKIMLPGVLRYE DGIEVNQEIVVITTKGEAIC MAIALMTTAVISTCDHGIVA KIKRVIMERDTYPRKWGLGP KASQKKLMIKQGLLDKHGKP TDSTPATWKQEYVDYSESAK KEVVAEVVKAPQVVAEAAKT AKRKRESESESDETPPAAPQ LIKKEKKKSKKDKKAKAGL |
| Tissue Specificity | Ubiquitously expressed. |
| Function | Isoform 1: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. Isoform 3: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression. |
| Protein Name | H/Aca Ribonucleoprotein Complex Subunit Dkc1 Cbf5 Homolog Dyskerin Nopp140-Associated Protein Of 57 Kda Nucleolar Protein Nap57 Nucleolar Protein Family A Member 4 Snornp Protein Dkc1 |
| Database Links | Reactome: R-HSA-171319 Reactome: R-HSA-6790901 |
| Cellular Localisation | Isoform 1: Nucleus Nucleolus Nucleus Cajal Body Also Localized To Cajal Bodies (Coiled Bodies) Isoform 3: Cytoplasm |
| Alternative Antibody Names | Anti-H/Aca Ribonucleoprotein Complex Subunit Dkc1 antibody Anti-Cbf5 Homolog antibody Anti-Dyskerin antibody Anti-Nopp140-Associated Protein Of 57 Kda antibody Anti-Nucleolar Protein Nap57 antibody Anti-Nucleolar Protein Family A Member 4 antibody Anti-Snornp Protein Dkc1 antibody Anti-DKC1 antibody Anti-NOLA4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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