Anti-DNMT3A antibody (600-700) (STJ28586) STJ28586|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-DNMT3A antibody (600-700) (STJ28586)
產品型號：STJ28586
產品廠商：ST john's laboratory
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簡單介紹：

Anti-DNMT3A antibody (600-700) (STJ28586)

詳情介紹：

Host:	Rabbit
Applications:	WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-DNMT3A (600-700) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	DNMT3A
Gene ID:	1788
Uniprot ID:	DNM3A_HUMAN
Immunogen Region:	600-700
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 600-700 of human DNMT3A (NP_072046.2).
Immunogen Sequence:	DWPSRLQMFFANNHDQEFDP PKVYPPVPAEKRKPIRVLSL FDGIATGLLVLKDLGIQVDR YIASEVCEDSITVGMVRHQG KIMYVGDVRSVTQKHIQEWG P

Tissue Specificity	Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung.
Post Translational Modifications	Sumoylated.sumoylation disrupts the ability to interact with histone deacetylases (HDAC1 and HDAC2) and repress transcription. Auto-methylated at Cys-710: auto-methylation takes place in absence of DNA substrate and inactivates the DNA methyltransferase activity. Inactivation by auto-methylation may be used to inactivate unused DNA methyltransferases in the cell.
Function	Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. Also has weak auto-methylation activity on Cys-710 in absence of DNA.
Protein Name	Dna Cytosine-5-Methyltransferase 3a Dnmt3a Cysteine Methyltransferase Dnmt3a Dna Methyltransferase Hsaiiia Dna Mtase Hsaiiia M.hsaiiia
Database Links	Reactome: R-HSA-212300 Reactome: R-HSA-3214858 Reactome: R-HSA-4655427 Reactome: R-HSA-5334118 Reactome: R-HSA-9710421
Cellular Localisation	Nucleus Chromosome Cytoplasm Accumulates In The Major Satellite Repeats At Pericentric Heterochromatin
Alternative Antibody Names	Anti-Dna antibody Anti-Cytosine-5-Methyltransferase 3a antibody Anti-Dnmt3a antibody Anti-Cysteine Methyltransferase Dnmt3a antibody Anti-Dna Methyltransferase Hsaiiia antibody Anti-Dna Mtase Hsaiiia antibody Anti-M.hsaiiia antibody Anti-DNMT3A antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-DNMT3A antibody (600-700) (STJ28586)