Anti-DNMT3B antibody (1-100) (STJ112939) STJ112939|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-DNMT3B antibody (1-100) (STJ112939)
產品型號：STJ112939
產品廠商：ST john's laboratory
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簡單介紹：

Anti-DNMT3B antibody (1-100) (STJ112939)

詳情介紹：

Host:	Rabbit
Applications:	WB/IHC
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-DNMT3B (1-100) is suitable for use in Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:200-1:1000 IHC-P 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	DNMT3B
Gene ID:	1789
Uniprot ID:	DNM3B_HUMAN
Immunogen Region:	1-100
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human DNMT3B (NP_008823.1).
Immunogen Sequence:	MKGDTRHLNGEEDAGGREDS ILVNGACSDQSSDSPPILEA IRTPEIRGRRSSSRLSKREV SSLLSYTQDLTGDGDGEDGD GSDTPVMPKLFRETRTRSES

Tissue Specificity	Ubiquitous.highly expressed in fetal liver, heart, kidney, placenta, and at lower levels in spleen, colon, brain, liver, small intestine, lung, peripheral blood mononuclear cells, and skeletal muscle. Isoform 1 is expressed in all tissues except brain, skeletal muscle and PBMC, 3 is ubiquitous, 4 is expressed in all tissues except brain, skeletal muscle, lung and prostate and 5 is detectable only in testis and at very low level in brain and prostate.
Post Translational Modifications	Sumoylated. Citrullinated by PADI4.
Function	Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Functions as a transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells.
Protein Name	Dna Cytosine-5-Methyltransferase 3b Dnmt3b Dna Methyltransferase Hsaiiib Dna Mtase Hsaiiib M.hsaiiib
Database Links	Reactome: R-HSA-212300 Reactome: R-HSA-427413 Reactome: R-HSA-4655427 Reactome: R-HSA-5334118 Reactome: R-HSA-9710421
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-Dna antibody Anti-Cytosine-5-Methyltransferase 3b antibody Anti-Dnmt3b antibody Anti-Dna Methyltransferase Hsaiiib antibody Anti-Dna Mtase Hsaiiib antibody Anti-M.hsaiiib antibody Anti-DNMT3B antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-DNMT3B antibody (1-100) (STJ112939)