Anti-E2F7 antibody (540-740) (STJ117405) STJ117405|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-E2F7 antibody (540-740) (STJ117405)
產品型號：STJ117405
產品廠商：ST john's laboratory
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Anti-E2F7 antibody (540-740) (STJ117405)

詳情介紹：

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-E2F7 (540-740) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	E2F7
Gene ID:	144455
Uniprot ID:	E2F7_HUMAN
Immunogen Region:	540-740
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 540-740 of human E2F7 (NP_976328.2).
Immunogen Sequence:	LLAGQPLVYVPSASLFMLYG SLQEGPASGSGSERDDRSSE APATVELSSAPSAQKRLCEE RKPQEEDEPATKRQSREYED GPLSLVMPKKPSDSTDLASP KTMGNRASIPLKDIHVNGQL PAAEEISGKATANSLVSSEW GNPSRNTDVEKPSKENESTK EPSLLQYLCVQSPAGLNGFN VLLSGSQTPPTVGPSSGQLP S

Function	Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTCCGCGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation.
Protein Name	Transcription Factor E2f7 E2f-7
Database Links	Reactome: R-HSA-6804116
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-Transcription Factor E2f7 antibody Anti-E2f-7 antibody Anti-E2F7 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-E2F7 antibody (540-740) (STJ117405)