Anti-EEF2K antibody (C-Term) (STJA0005388) STJA0005388-100|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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Anti-EEF2K antibody (C-Term) (STJA0005388)

詳情介紹：

Host:	Rabbit
Applications:	WB/ICC/IP
Reactivity:	Chicken/Human/Mouse/Rat/Xenopus
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-eEF2K (C-Term) is suitable for use in Western Blot, Immunocytochemistry and Immunoprecipitation research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Purification:	Antigen Affinity Purified
Dilution Range:	WB 1:1000 IHC ICC 1:200 IP 1:100
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	EEF2K
Gene ID:	29904
Uniprot ID:	EF2K_HUMAN
Immunogen Region:	C-Term
Specificity:	The antibody detects a 105 kDa* protein corresponding to the molecular mass of eEF2K on SDS-PAGE immunoblots of human A431, HeLa, and Jurkat cells. The antibody also detected eEF2K in immunoprecipitations in HeLa cells and immunofluorescent labeling
Immunogen:	eEF2K (C-terminus) synthetic peptide (coupled to carrier protein) corresponds to amino acids in the C-terminal region of human eEF2K. This sequence is well conserved in rat, mouse, chicken, and fish eEF2K, and has low homology to other proteins.

Post Translational Modifications	Autophosphorylated at multiple residues, Thr-348 being the major site. Phosphorylated by AMP-activated protein kinase AMPK at Ser-398 leading to EEF2K activation and protein synthesis inhibition. Phosphorylated by TRPM7 at Ser-78 resulting in improved protein stability, higher EE2F phosphorylated and subsequently reduced rate of protein synthesis. Phosphorylation by other kinases such as CDK1 and MAPK13 at Ser-359 or RPS6KA1 and RPS6KB1 at Ser-366 instead decrease EEF2K activity and promote protein synthesis.
Function	Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.
Protein Name	Eukaryotic Elongation Factor 2 Kinase Eef-2 Kinase Eef-2k Calcium/Calmodulin-Dependent Eukaryotic Elongation Factor 2 Kinase
Database Links	Reactome: R-HSA-166208
Alternative Antibody Names	Anti-Eukaryotic Elongation Factor 2 Kinase antibody Anti-Eef-2 Kinase antibody Anti-Eef-2k antibody Anti-Calcium/Calmodulin-Dependent Eukaryotic Elongation Factor 2 Kinase antibody Anti-EEF2K antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-EEF2K antibody (C-Term) (STJA0005388)