Anti-EIF2AK1 antibody (337-630) (STJ116054) STJ116054|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-EIF2AK1 antibody (337-630) (STJ116054)
產品型號：STJ116054
產品廠商：ST john's laboratory
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Anti-EIF2AK1 antibody (337-630) (STJ116054)

詳情介紹：

Host:	Rabbit
Applications:	WB/IHC
Reactivity:	Human/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-EIF2AK1 (337-630) is suitable for use in Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IHC-P 1:100-1:500
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	EIF2AK1
Gene ID:	27102
Uniprot ID:	E2AK1_HUMAN
Immunogen Region:	337-630
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 337-630 of human EIF2AK1 (NP_055228.2).
Immunogen Sequence:	SIVEQQLPLRRNSHLEESFT STEESSEENVNFLGQTEAQY HLMLHIQMQLCELSLWDWIV ERNKRGREYVDESACPYVMA NVATKIFQELVEGVFYIHNM GIVHRDLKPRNIFLHGPDQQ VKIGDFGLACTDILQKNTDW TNRNGKRTPTHTSRVGTCLY ASPEQLEGSEYDAKSDMYSL GVVLLELFQPFGTEMERAEV LTGLRTGQLPESLRKRCPVQ AKYIQHLTRRNSSQRPSAI

Post Translational Modifications	Activated by autophosphorylation.phosphorylated predominantly on serine and threonine residues, but also on tyrosine residues. Autophosphorylation at Thr-488 is required for kinase activation. The active autophosphorylated form apparently is largely refractory to cellular heme fluctuations.
Function	Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions. Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock. EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming. Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties. It thereby plays an essential protective role for RBC survival in anemias of iron deficiency. Iron deficiency also triggers activation by full-length DELE1. Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming.
Protein Name	Eukaryotic Translation Initiation Factor 2-Alpha Kinase 1 Heme-Controlled Repressor Hcr Heme-Regulated Eukaryotic Initiation Factor Eif-2-Alpha Kinase Heme-Regulated Inhibitor Hhri Hemin-Sensitive Initiation Factor 2-Alpha Kinase
Database Links	Reactome: R-HSA-9648895
Alternative Antibody Names	Anti-Eukaryotic Translation Initiation Factor 2-Alpha Kinase 1 antibody Anti-Heme-Controlled Repressor antibody Anti-Hcr antibody Anti-Heme-Regulated Eukaryotic Initiation Factor Eif-2-Alpha Kinase antibody Anti-Heme-Regulated Inhibitor antibody Anti-Hhri antibody Anti-Hemin-Sensitive Initiation Factor 2-Alpha Kinase antibody Anti-EIF2AK1 antibody Anti-HRI antibody Anti-KIAA1369 antibody Anti-PRO1362 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-EIF2AK1 antibody (337-630) (STJ116054)