產品詳情
簡單介紹：
Anti-Cd48 antibody [HM48-1] {AF647} (STJA0000221)
詳情介紹：
| Host: | Armenian Hamster |
| Applications: | FC |
| Reactivity: | Mouse |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: | Armenian Hamster monoclonal antibody anti-CD48 antigen is suitable for use in Flow Cytometry research applications. |
| Clonality: | Monoclonal |
| Clone ID: | HM48-1 |
| Conjugation: | AF647 |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 1% BSA |
| Storage Instruction: | Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
| Gene Symbol: | Cd48 |
| Gene ID: | 12506 |
| Uniprot ID: | CD48_MOUSE |
| Function | Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells. |
| Protein Name | Cd48 Antigen Bcm1 Surface Antigen Blast-1 Hm48-1 Mrc Ox-45 Surface Antigen Slam Family Member 2 Slamf2 Signaling Lymphocytic Activation Molecule 2 Sgp-60 Cd Antigen Cd48 |
| Database Links | Reactome: R-MMU-202733 |
| Cellular Localisation | Cell Membrane Lipid-Anchor Gpi-Anchor Secreted |
| Alternative Antibody Names | Anti-Cd48 Antigen antibody Anti-Bcm1 Surface Antigen antibody Anti-Blast-1 antibody Anti-Hm48-1 antibody Anti-Mrc Ox-45 Surface Antigen antibody Anti-Slam Family Member 2 antibody Anti-Slamf2 antibody Anti-Signaling Lymphocytic Activation Molecule 2 antibody Anti-Sgp-60 antibody Anti-Cd Antigen Cd48 antibody Anti-Cd48 antibody Anti-Bcm-1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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