Mouse NNMT (Nicotinamide-N-Methyltransferase) Sandwich ELISA Kit (STJE0010996) STJE0010996|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Mouse NNMT (Nicotinamide-N-Methyltransferase) Sandwich ELISA Kit (STJE0010996)
產品型號：STJE0010996
產品廠商：ST john's laboratory
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簡單介紹：

Mouse NNMT (Nicotinamide-N-Methyltransferase) Sandwich ELISA Kit (STJE0010996)

詳情介紹：

Applications:	ELISA
Reactivity:	Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.055ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This NNMT Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	Nnmt
Gene ID:	18113
Uniprot ID:	NNMT_MOUSE
Sample Type:	serum, plasma or other biological fluids.

Tissue Specificity	Expressed in white adipose tissue and liver (at protein level).
Post Translational Modifications	Deiminated by PADI1 and PADI2.
Function	Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway. Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases. Actively mediates genome-wide epigenetic and transcriptional changes through hypomethylation of repressive chromatin marks, such as H3K27me3. In a developmental context, contributes to low levels of the repressive histone marks that characterize pluripotent embryonic stem cell pre-implantation state. Acts as a metabolic regulator primarily on white adipose tissue energy expenditure as well as hepatic gluconeogenesis and cholesterol biosesynthesis. In white adipocytes, regulates polyamine flux by consuming S-adenosyl-L-methionine which provides for propylamine group in polyamine biosesynthesis, whereas by consuming nicotinamide controls NAD(+) levels through the salvage pathway. Via its product N1-methylnicotinamide regulates protein acetylation in hepatocytes, by repressing the ubiquitination and increasing the stability of SIRT1 deacetylase. Can also N-methylate other pyridines structurally related to nicotinamide and play a role in xenobiotic detoxification.
Protein Name	Nicotinamide N-Methyltransferase
Database Links	Reactome: R-MMU-156581 Reactome: -MMU-197264
Cellular Localisation	Cytoplasm
Alternative ELISA Names	Nicotinamide N-Methyltransferase ELISA kit Nnmt ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Mouse NNMT (Nicotinamide-N-Methyltransferase) Sandwich ELISA Kit (STJE0010996)