產品詳情
簡單介紹：
Anti-ELP3 antibody (1-547) [S2MR] (STJ11101222)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit monoclonal antibody anti-KAT9/Elp3 (1-547) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: | Monoclonal |
| Clone ID: | S2MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000 IHC-P 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ELP3 |
| Gene ID: | 55140 |
| Uniprot ID: | ELP3_HUMAN |
| Immunogen Region: | 1-547 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-547 of human KAT9/Elp3 (Q9H9T3). |
| Immunogen Sequence: | MRQKRKGDLSPAELMMLTIG DVIKQLIEAHEQGKDIDLNK VKTKTAAKYGLSAQPRLVDI IAAVPPQYRKVLMPKLKAKP IRTASGIAVVAVMCKPHRCP HISFTGNICVYCPGGPDSDF EYSTQSYTGYEPTSMRAIRA RYDPFLQTRHRIEQLKQLGH SVDKVEFIVMGGTFMALPEE YRDYFIRNLHDALSGHTSNN IYEAVKYSERSLTKCIGITI ETRPDYCMKRHLSDMLTYG |
| Tissue Specificity | Expressed in the cerebellum and spinal motor neurons. |
| Post Translational Modifications | Tyrosine-phosphorylated.phosphorylation on Tyr-202 does not affect elongator complex integrity or ELP3 protein stability. Also serine/threonine-phosphorylated. |
| Function | Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins.such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase. Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. Required for acetylation of GJA1 in the developing cerebral cortex. |
| Protein Name | Elongator Complex Protein 3 Help3 Trna Uridine(34 Acetyltransferase |
| Database Links | Reactome: R-HSA-3214847 |
| Cellular Localisation | Cytoplasm Nucleus Isoform 1: Nucleus Isoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Elongator Complex Protein 3 antibody Anti-Help3 antibody Anti-Trna Uridine(34 Acetyltransferase antibody Anti-ELP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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