Mouse PP2Aa (Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Alpha Isoform) Sandwich ELISA Kit (STJE0011602) STJE0011602|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Mouse PP2Aa (Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Alpha Isoform) Sandwich ELISA Kit (STJE0011602)
產品型號：STJE0011602
產品廠商：ST john's laboratory
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Mouse PP2Aa (Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Alpha Isoform) Sandwich ELISA Kit (STJE0011602)

詳情介紹：

Applications:	ELISA
Reactivity:	Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	34.6pg/mL
Detection Limit:	78.1-5000pg/mL
Short Description:	This PP2Aa Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	Ppp2r1a
Gene ID:	51792
Uniprot ID:	2AAA_MOUSE
Sample Type:	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity
Post Translational Modifications
Function	The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis. Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway. Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability.
Protein Name	Serine/Threonine-Protein Phosphatase 2a 65 Kda Regulatory Subunit A Alpha Isoform Pp2a Subunit A Isoform Pr65-Alpha Pp2a Subunit A Isoform R1-Alpha
Database Links	Reactome: R-MMU-113501 Reactome: -MMU-1295596 Reactome: -MMU-141444 Reactome: -MMU-180024 Reactome: -MMU-195253 Reactome: -MMU-196299 Reactome: -MMU-198753 Reactome: -MMU-202670 Reactome: -MMU-2467813 Reactome: -MMU-2500257 Reactome: -MMU-2565942 Reactome: -MMU-2995383 Reactome: -MMU-380259 Reactome: -MMU-380270 Reactome: -MMU-380284 Reactome: -MMU-380320 Reactome: -MMU-389513 Reactome: -MMU-432142 Reactome: -MMU-4641262 Reactome: -MMU-5620912 Reactome: -MMU-5663220 Reactome: -MMU-5673000 Reactome: -MMU-5675221 Reactome: -MMU-6804757 Reactome: -MMU-6811558 Reactome: -MMU-68877 Reactome: -MMU-69231 Reactome: -MMU-69273 Reactome: -MMU-8854518 Reactome: -MMU-9648025 Reactome: -MMU-975957
Cellular Localisation	Cytoplasm Nucleus Chromosome Centromere Lateral Cell Membrane Cell Projection Dendrite Centromeric Localization Requires The Presence Of Bub1
Alternative ELISA Names	Serine/Threonine-Protein Phosphatase 2a 65 Kda Regulatory Subunit A Alpha Isoform ELISA kit Pp2a Subunit A Isoform Pr65-Alpha ELISA kit Pp2a Subunit A Isoform R1-Alpha ELISA kit Ppp2r1a ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Mouse PP2Aa (Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Alpha Isoform) Sandwich ELISA Kit (STJE0011602)