Anti-EPHA3 antibody (900-980) {FITC} (STJ500914) STJ500914-100|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-EPHA3 antibody (900-980) {FITC} (STJ500914)
產品型號：STJ500914-100
產品廠商：ST john's laboratory
產品文檔：

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簡單介紹：

Anti-EPHA3 antibody (900-980) {FITC} (STJ500914)

詳情介紹：

Host:	Rabbit
Applications:	ELISA/WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-EPHA3 (900-980) is suitable for use in ELISA and Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	FITC
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.55-0.75 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:200
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	EPHA3
Gene ID:	2042
Uniprot ID:	EPHA3_HUMAN
Immunogen Region:	900-980
Immunogen:	Synthetic peptide taken within amino acid region 900-980 on human EPHA3 protein

Tissue Specificity	Widely expressed. Highest level in placenta.
Post Translational Modifications	Autophosphorylates upon activation by EFNA5. Phosphorylation on Tyr-602 mediates interaction with NCK1. Dephosphorylated by PTPN1.
Function	Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.
Protein Name	Ephrin Type-A Receptor 3 Eph-Like Kinase 4 Ek4 Hek4 Hek Human Embryo Kinase Tyrosine-Protein Kinase Tyro4 Tyrosine-Protein Kinase Receptor Etk1 Eph-Like Tyrosine Kinase 1
Database Links	Reactome: R-HSA-2682334 Reactome: R-HSA-3928663 Reactome: R-HSA-3928665
Cellular Localisation	Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Secreted
Alternative Antibody Names	Anti-Ephrin Type-A Receptor 3 antibody Anti-Eph-Like Kinase 4 antibody Anti-Ek4 antibody Anti-Hek4 antibody Anti-Hek antibody Anti-Human Embryo Kinase antibody Anti-Tyrosine-Protein Kinase Tyro4 antibody Anti-Tyrosine-Protein Kinase Receptor Etk1 antibody Anti-Eph-Like Tyrosine Kinase 1 antibody Anti-EPHA3 antibody Anti-ETK antibody Anti-ETK1 antibody Anti-HEK antibody Anti-TYRO4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-EPHA3 antibody (900-980) {FITC} (STJ500914)