Anti-Ephrin A1 antibody (1-100) [S0MR] (STJ11103650) STJ11103650|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-Ephrin A1 antibody (1-100) [S0MR] (STJ11103650)
產品型號：STJ11103650
產品廠商：ST john's laboratory
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簡單介紹：

Anti-Ephrin A1 antibody (1-100) [S0MR] (STJ11103650)

詳情介紹：

Host:	Rabbit
Applications:	WB/IHC/IF
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-Ephrin A1 (1-100) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Monoclonal
Clone ID:	S0MR
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	EFNA1
Gene ID:	1942
Uniprot ID:	EFNA1_HUMAN
Immunogen Region:	1-100
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Ephrin A1 (P20827).
Immunogen Sequence:	MEFLWAPLLGLCCSLAAADR HTVFWNSSNPKFRNEDYTIH VQLNDYVDIICPHYEDHSVA DAAMEQYILYLVEHEEYQLC QPQSKDQVRWQCNRPSAKHG

Tissue Specificity	Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level).
Post Translational Modifications	Undergoes proteolysis by a metalloprotease to give rise to a soluble monomeric form. N-Glycosylation is required for binding to EPHA2 receptor and inducing its internalization.
Function	Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.
Protein Name	Ephrin-A1 Eph-Related Receptor Tyrosine Kinase Ligand 1 Lerk-1 Immediate Early Response Protein B61 Tumor Necrosis Factor Alpha-Induced Protein 4 Tnf Alpha-Induced Protein 4 Cleaved Into - Ephrin-A1 - Secreted Form
Database Links	Reactome: R-HSA-2682334 Reactome: R-HSA-3928663 Reactome: R-HSA-3928665
Cellular Localisation	Cell Membrane Lipid-Anchor Gpi-Anchor Ephrin-A1 Secreted Form: Secreted
Alternative Antibody Names	Anti-Ephrin-A1 antibody Anti-Eph-Related Receptor Tyrosine Kinase Ligand 1 antibody Anti-Lerk-1 antibody Anti-Immediate Early Response Protein B61 antibody Anti-Tumor Necrosis Factor Alpha-Induced Protein 4 antibody Anti-Tnf Alpha-Induced Protein 4 Cleaved Into - Ephrin-A1 - Secreted Form antibody Anti-EFNA1 antibody Anti-EPLG1 antibody Anti-LERK1 antibody Anti-TNFAIP4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-Ephrin A1 antibody (1-100) [S0MR] (STJ11103650)