Anti-ERCC1 antibody (1-323) (STJ11100039) STJ11100039|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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Anti-ERCC1 antibody (1-323) (STJ11100039)

詳情介紹：

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-ERCC1 (1-323) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ERCC1
Gene ID:	2067
Uniprot ID:	ERCC1_HUMAN
Immunogen Region:	1-323
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human ERCC1 (NP_973730.1).
Immunogen Sequence:	MDPGKDKEGVPQPSGPPARK KFVIPLDEDEVPPGVAKPLF RSTQSLPTVDTSAQAAPQTY AEYAISQPLEGAGATCPTGS EPLAGETPNQALKPGAKSNS IIVSPRQRGNPVLKFVRNVP WEFGDVIPDYVLGQSTCALF LSLRYHNLHPDYIHGRLQSL GKNFALRVLLVQVDVKDPQQ ALKELAKMCILADCTLILAW SPEEAGRYLETYKAYEQKPA DLLMEKLEQDFVSRVTECL

Post Translational Modifications	Ubiquitinated with both 'Lys-48' and 'Lys-63' linkages. Deubiquitinated by USP45.
Function	Isoform 1: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. Isoform 2: Not functional in the nucleotide excision repair pathway. Isoform 3: Not functional in the nucleotide excision repair pathway. Isoform 4: Not functional in the nucleotide excision repair pathway.
Protein Name	Dna Excision Repair Protein Ercc-1
Database Links	Reactome: R-HSA-5685938 Reactome: R-HSA-5696395 Reactome: R-HSA-5696400 Reactome: R-HSA-6782135 Reactome: R-HSA-6783310
Cellular Localisation	Isoform 1: Nucleus Isoform 2: Cytoplasm Nucleus Isoform 3: Nucleus Isoform 4: Nucleus
Alternative Antibody Names	Anti-Dna Excision Repair Protein Ercc-1 antibody Anti-ERCC1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-ERCC1 antibody (1-323) (STJ11100039)