Anti-ERO1LB antibody (34-230) (STJ26443) STJ26443|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-ERO1LB antibody (34-230) (STJ26443)
產品型號：STJ26443
產品廠商：ST john's laboratory
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簡單介紹：

Anti-ERO1LB antibody (34-230) (STJ26443)

詳情介紹：

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-ERO1LB (34-230) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ERO1B
Gene ID:	56605
Uniprot ID:	ERO1B_HUMAN
Immunogen Region:	34-230
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 34-230 of human ERO1LB (NP_063944.3).
Immunogen Sequence:	QVTGVLDDCLCDIDSIDNFN TYKIFPKIKKLQERDYFRYY KVNLKRPCPFWAEDGHCSIK DCHVEPCPESKIPVGIKAGH SNKYLKMANNTKELEDCEQA NKLGAINSTLSNQSKEAFID WARYDDSRDHFCELDDERSP AAQYVDLLLNPERYTGYKGT SAWRVWNSIYEENCFKPRSV YRPLNPLAPSRGEDDGE

Tissue Specificity	Highly expressed in the digestive tract, including the duodenum and lower digestive tract. In the stomach, highly expressed in enzyme-producing chief cells (at protein level). In the pancreas, expressed in islets of Langerhans and, at lower levels, in enzyme-secreting cells (at protein level). Detected at low level in many other tissues.
Post Translational Modifications	N-glycosylated. The Cys-90/Cys-95 and Cys-393/Cys-396 disulfide bonds constitute the redox-active center. The Cys-90/Cys-95 disulfide bond accepts electron from P4HB and funnel them to the active site disulfide Cys-393/Cys-396. The Cys-81/Cys-390 disulfide bond may be critical for structural stability. Two long-range disulfide bonds participate in loose feedback regulation. The Cys-90/Cys-130 disulfide bond may be the predominant regulatory switch to modulate the catalytic activity, while the Cys-100/Cys-262 disulfide bond may play an auxiliary regulatory role.
Function	Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%). following="" p4hb="" reoxidation,="" passes="" its="" electrons="" to="" molecular="" oxygen="" via="" fad,="" leading="" the="" production="" of="" reactive="" species="" (ros)="" in="" cell.="" may="" be="" involved="" oxidative="" proinsulin="" folding="" pancreatic="" cells,="" hence="" play="" a="" role="" glucose="" homeostasis.="" <="" td="">
Protein Name	Ero1-Like Protein Beta Ero1-L-Beta Endoplasmic Reticulum Oxidoreductase Beta Endoplasmic Reticulum Oxidoreductin-1-Like Protein B Oxidoreductin-1-L-Beta
Database Links	Reactome: R-HSA-264876
Cellular Localisation	Endoplasmic Reticulum Membrane Peripheral Membrane Protein Lumenal Side The Association With Erp44 May Be Essential For Its Retention In The Endoplasmic Reticulum
Alternative Antibody Names	Anti-Ero1-Like Protein Beta antibody Anti-Ero1-L-Beta antibody Anti-Endoplasmic Reticulum Oxidoreductase Beta antibody Anti-Endoplasmic Reticulum Oxidoreductin-1-Like Protein B antibody Anti-Oxidoreductin-1-L-Beta antibody Anti-ERO1B antibody Anti-ERO1LB antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-ERO1LB antibody (34-230) (STJ26443)