產品詳情
簡單介紹：
Anti-Cd86 antibody [GL-1] {AF488} (STJA0000102)
詳情介紹：
| Host: | Rat |
| Applications: | FC |
| Reactivity: | Mouse |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: | Rat monoclonal antibody anti-T-lymphocyte activation antigen CD86 is suitable for use in Flow Cytometry research applications. |
| Clonality: | Monoclonal |
| Clone ID: | GL-1 |
| Conjugation: | AF488 |
| Isotype: | IgG2ak |
| Formulation: | PBS with 0.05% Proclin300, 1% BSA |
| Storage Instruction: | Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
| Gene Symbol: | Cd86 |
| Gene ID: | 12524 |
| Uniprot ID: | CD86_MOUSE |
| Tissue Specificity | Expressed on activated B-cells. |
| Post Translational Modifications | Polyubiquitinated.which is promoted by MARCH8 and results in endocytosis and lysosomal degradation. |
| Function | Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation. |
| Protein Name | T-Lymphocyte Activation Antigen Cd86 Activation B7-2 Antigen Early T-Cell Costimulatory Molecule 1 Etc-1 Cd Antigen Cd86 |
| Database Links | Reactome: R-MMU-1257604 Reactome: -MMU-389356 Reactome: -MMU-389357 Reactome: -MMU-389359 Reactome: -MMU-389513 Reactome: -MMU-6811558 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-T-Lymphocyte Activation Antigen Cd86 antibody Anti-Activation B7-2 Antigen antibody Anti-Early T-Cell Costimulatory Molecule 1 antibody Anti-Etc-1 antibody Anti-Cd Antigen Cd86 antibody Anti-Cd86 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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