產品詳情
簡單介紹:
Mouse SPTLC3 (Serine Palmitoyltransferase, Long Chain Base Subunit 3) Sandwich ELISA Kit Ready-To-Use (STJE0018718)
詳情介紹:
Applications: | ELISA |
Reactivity: | Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Sensitivity: | 0.061ng/mL |
Detection Limit: | 0.156-10ng/mL |
Short Description: | This SPTLC3 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
Assay Time: | 3 hrs |
Gene Symbol: | Sptlc3 |
Gene ID: | 228677 |
Uniprot ID: | SPTC3_MOUSE |
Immunogen Region: | Ready-To-Use |
Sample Type: | tissue homogenates, cell lysates or other biological fluids. |
Tissue Specificity | Expressed in white and brown adipose tissues. |
Post Translational Modifications | |
Function | Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosesynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. |
Protein Name | Serine Palmitoyltransferase 3 Long Chain Base Biosesynthesis Protein 2b Lcb2b Long Chain Base Biosesynthesis Protein 3 Lcb 3 Serine-Palmityl-Coa Transferase 3 Spt 3 |
Database Links | Reactome: R-MMU-1660661 |
Cellular Localisation | Endoplasmic Reticulum Membrane Single-Pass Membrane Protein |
Alternative ELISA Names | Serine Palmitoyltransferase 3 ELISA kit Long Chain Base Biosesynthesis Protein 2b ELISA kit Lcb2b ELISA kit Long Chain Base Biosesynthesis Protein 3 ELISA kit Lcb 3 ELISA kit Serine-Palmityl-Coa Transferase 3 ELISA kit Spt 3 ELISA kit Sptlc3 ELISA kit Sptlc2l ELISA kit |
output |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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