產品詳情
簡單介紹：
Anti-EXO1 antibody (601-846) (STJ29872)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-EXO1 (601-846) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 IHC-P 1:50-1:100 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EXO1 |
| Gene ID: | 9156 |
| Uniprot ID: | EXO1_HUMAN |
| Immunogen Region: | 601-846 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 601-846 of human EXO1 (NP_006018.4). |
| Immunogen Sequence: | TLGTLRSCFSWSGGLGDFSR TPSPSPSTALQQFRRKSDSP TSLPENNMSDVSQLKSEESS DDESHPLREEACSSQSQESG EFSLQSSNASKLSQCSSKDS DSEESDCNIKLLDSQSDQTS KLRLSHFSKKDTPLRNKVPG LYKSSSADSLSTTKIKPLGP ARASGLSKKPASIQKRKHHN AENKPGLQIKLNELWKNFGF KKDSEKLPPCKKPLSPVRDN IQLTPEAEEDIFNKPECGR |
| Tissue Specificity | Highly expressed in bone marrow, testis and thymus. Expressed at lower levels in colon, lymph nodes, ovary, placenta, prostate, small intestine, spleen and stomach. |
| Post Translational Modifications | Phosphorylated upon DNA damage and in response to agents stalling DNA replication, probably by ATM or ATR. Phosphorylation at Ser-454, Thr-621 and Ser-714 is induced upon DNA-damage caused by treatment with hydroxyurea (HU) but not upon IR treatment. The HU-induced EXO1 triple phosphorylation facilitates destabilization/degradation of the protein. |
| Function | 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosesis. |
| Protein Name | Exonuclease 1 Hexo1 Exonuclease I Hexoi |
| Database Links | Reactome: R-HSA-5358565 Reactome: R-HSA-5358606 Reactome: R-HSA-5685938 Reactome: R-HSA-5685942 Reactome: R-HSA-5693554 Reactome: R-HSA-5693568 Reactome: R-HSA-5693579 Reactome: R-HSA-5693607 Reactome: R-HSA-5693616 Reactome: R-HSA-6804756 Reactome: R-HSA-69473 Reactome: R-HSA-9701192 Reactome: R-HSA-9704331 Reactome: R-HSA-9704646 Reactome: R-HSA-9709570 Reactome: R-HSA-9709603 |
| Cellular Localisation | Nucleus Colocalizes With Pcna To Discrete Nuclear Foci In S-Phase |
| Alternative Antibody Names | Anti-Exonuclease 1 antibody Anti-Hexo1 antibody Anti-Exonuclease I antibody Anti-Hexoi antibody Anti-EXO1 antibody Anti-EXOI antibody Anti-HEX1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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