產品詳情
簡單介紹:
Anti-EXT2 antibody (80-340) (STJ111122)
詳情介紹:
Host: | Rabbit |
Applications: | WB/IF |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-EXT2 (80-340) is suitable for use in Western Blot and Immunofluorescence research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 IF/ICC 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | EXT2 |
Gene ID: | 2132 |
Uniprot ID: | EXT2_HUMAN |
Immunogen Region: | 80-340 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 80-340 of human EXT2 (NP_000392.3). |
Immunogen Sequence: | PHSIESSNDWNVEKRSIRDV PVVRLPADSPIPERGDLSCR MHTCFDVYRCGFNPKNKIKV YIYALKKYVDDFGVSVSNTI SREYNELLMAISDSDYYTDD INRACLFVPSIDVLNQNTLR IKETAQAMAQLSRWDRGTNH LLFNMLPGGPPDYNTALDVP RDRALLAGGGFSTWTYRQGY DVSIPVYSPLSAEVDLPEKG PGPRQYFLLSSQVGLHPEYR EDLEALQVKHGESVLVLDK |
Tissue Specificity | Ubiquitous. |
Function | Glycosyltransferase required for the biosesynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan. |
Protein Name | Exostosin-2 Glucuronosyl-N-Acetylglucosaminyl-Proteoglycan/N-Acetylglucosaminyl-Proteoglycan 4-Alpha-N-Acetylglucosaminyltransferase Multiple Exostoses Protein 2 Putative Tumor Suppressor Protein Ext2 |
Database Links | Reactome: R-HSA-2022928 Reactome: R-HSA-3656237 Reactome: R-HSA-3656253 |
Cellular Localisation | Endoplasmic Reticulum Membrane Single-Pass Type Ii Membrane Protein Golgi Apparatus Membrane Golgi Apparatus Cis-Golgi Network Membrane The Ext1/Ext2 Complex Is Localized In The Golgi Apparatus |
Alternative Antibody Names | Anti-Exostosin-2 antibody Anti-Glucuronosyl-N-Acetylglucosaminyl-Proteoglycan/N-Acetylglucosaminyl-Proteoglycan 4-Alpha-N-Acetylglucosaminyltransferase antibody Anti-Multiple Exostoses Protein 2 antibody Anti-Putative Tumor Suppressor Protein Ext2 antibody Anti-EXT2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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