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Anti-EYA3 antibody (STJA0007309) STJA0007309|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司
產品詳情

  • 產品名稱：Anti-EYA3 antibody (STJA0007309)

  • 產品型號：STJA0007309
  • 產品廠商：ST john's laboratory
  • 產品文檔：
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簡單介紹：
Anti-EYA3 antibody (STJA0007309)
詳情介紹：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Eyes absent homolog 3 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EYA3
Gene ID: 2140
Uniprot ID: EYA3_HUMAN
Specificity: This antibody detects endogenous levels of EYA3 at Human, Mouse
Immunogen: Synthesized peptide derived from human EYA3
Function Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity. May be involved in development of the eye.
Protein Name Eyes Absent Homolog 3
Database Links Reactome: R-HSA-5693565
Cellular Localisation Cytoplasm
Nucleus
Localizes At Sites Of Dna Damage At Double-Strand Breaks (Dsbs)
With Decreasing Efficiency
Translocalized To The Nucleus By Six2 And Six5
And Six4
Respectively
Alternative Antibody Names Anti-Eyes Absent Homolog 3 antibody
Anti-EYA3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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