產品詳情
簡單介紹：
Anti-EZR antibody (350-470) (STJ29814)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/IF/IP |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-EZR (350-470) is suitable for use in Western Blot, Immunofluorescence and Immunoprecipitation research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 IF/ICC 1:50-1:100 IP 1:50-1:100 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EZR |
| Gene ID: | 7430 |
| Uniprot ID: | EZRI_HUMAN |
| Immunogen Region: | 350-470 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-470 of human Ezrinin (NP_003370.2). |
| Immunogen Sequence: | RLQDYEEKTKKAERELSEQI QRALQLEEERKRAQEEAERL EADRMAALRAKEELERQAVD QIKSQEQLAAELAEYTAKIA LLEEARRRKEDEVEEWQHRA KEAQDDLVKTKEELHLVMTA P |
| Tissue Specificity | Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied. |
| Post Translational Modifications | Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding. S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex. |
| Function | Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. |
| Protein Name | Ezrin Cytovillin Villin-2 P81 |
| Database Links | Reactome: R-HSA-373752 Reactome: R-HSA-437239 Reactome: R-HSA-9662360 Reactome: R-HSA-9662361 |
| Cellular Localisation | Apical Cell Membrane Peripheral Membrane Protein Cytoplasmic Side Cell Projection Microvillus Membrane Ruffle Membrane Cytoplasm Cell Cortex Cytoskeleton Microvillus Localization To The Apical Membrane Of Parietal Cells Depends On The Interaction With Pals1 Localizes To Cell Extensions And Peripheral Processes Of Astrocytes Microvillar Peripheral Membrane Protein (Cytoplasmic Side) |
| Alternative Antibody Names | Anti-Ezrin antibody Anti-Cytovillin antibody Anti-Villin-2 antibody Anti-P81 antibody Anti-EZR antibody Anti-VIL2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
相關信息
![Anti-14-3-3 beta/Theta antibody (1-100) [S1MR] (STJ11103651)](http://y1.yzimgs.com/uploads/465546/2024520-20551366.png?imageView2/2/w/200/h/200)
- 細胞培養玄學-MRC-5細胞 2025-01-07
- Ocean NanoTech定製的詳細步驟 2021-10-31
- LaysanBio代理商相關文獻資料2020 2021-10-31
- click chemistry tools數據結果比... 2021-10-31
- Abbiotec代理的產品得到重複驗證2020 2021-10-31
- zyagen Laboratories代理的產品得到... 2021-06-20
- Toxin Technologies代理商相關文獻資... 2021-03-14
- 熱烈祝賀91麻豆福利视频网生物正式代理biocolor公司試劑產品... 2021-03-14
- 熱烈祝賀91麻豆福利视频网生物正式代理cytognos公司試劑產品... 2021-03-14
- Gelest代理的產品得到重複驗證2020 2021-03-14
