Mouse TMEM27 (Transmembrane Protein 27) Sandwich ELISA Kit Ready-To-Use (STJE0019040) STJE0019040|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Mouse TMEM27 (Transmembrane Protein 27) Sandwich ELISA Kit Ready-To-Use (STJE0019040)
產品型號：STJE0019040
產品廠商：ST john's laboratory
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Mouse TMEM27 (Transmembrane Protein 27) Sandwich ELISA Kit Ready-To-Use (STJE0019040)

詳情介紹：

Applications:	ELISA
Reactivity:	Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.053ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This TMEM27 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	Cltrn
Gene ID:	57394
Uniprot ID:	CLTRN_MOUSE
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Expressed on the apical surface of the proximal tubules in the renal cortex (at protein level). Kidney.collecting ducts and proximal tubule. Pancreas.beta cells of islets. Expressed in the cerebral cortex, hippocampus, brainstem and cerebellum.
Post Translational Modifications	Glycosylated. Glycosylation is required for plasma membrane localization and for its cleavage by BACE2. Proteolytically processed in pancreatic beta cells by BACE2 leading to the generation and extracellular release of soluble CLTRN, and a corresponding cell-associated C-terminal fragment which is later cleaved by gamma-secretase. This shedding process inactivates CLTRN. Three cleavage sites have been identified for BACE2, two clustered sites after Phe-116 and Leu-118 and a more membrane proximal site at Phe-125.the preferred BACE2 cleavage site seems to be between Phe-125 and Leu-126, Phe-116 and Leu-118 act as alternative sites.
Function	Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their activity. May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane. Regulator of SNARE complex function. Stimulator of beta cell replication.
Protein Name	Collectrin Transmembrane Protein 27
Database Links
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Localizes To The Brush Border Membranes Of Cells In The Proximal Tubules Of Kidney Colocalizes With Slc6a19 In The Early Proximal S1 Tubule
Alternative ELISA Names	Collectrin ELISA kit Transmembrane Protein 27 ELISA kit Cltrn ELISA kit Nx17 ELISA kit Tmem27 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Mouse TMEM27 (Transmembrane Protein 27) Sandwich ELISA Kit Ready-To-Use (STJE0019040)