產品詳情
簡單介紹：
Anti-F2R antibody (42-425) (STJ27608)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-F2R (42-425) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | F2R |
| Gene ID: | 2149 |
| Uniprot ID: | PAR1_HUMAN |
| Immunogen Region: | 42-425 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 42-425 of human F2R (NP_001983.2). |
| Immunogen Sequence: | SFLLRNPNDKYEPFWEDEEK NESGLTEYRLVSINKSSPLQ KQLPAFISEDASGYLTSSWL TLFVPSVYT |
| Tissue Specificity | Platelets and vascular endothelial cells. |
| Post Translational Modifications | Proteolytic cleavage by thrombin generates a new N-terminus that functions as a tethered ligand. Also proteolytically cleaved by cathepsin CTSG. Cleavage at 41-Arg-|-Ser-42 by CTSG results in receptor activation while cleavage at 55-Phe-|-Trp-56 results in inhibition of receptor activation. Phosphorylated in the C-terminal tail.probably mediating desensitization prior to the uncoupling and internalization of the receptor. |
| Function | High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. |
| Protein Name | Proteinase-Activated Receptor 1 Par-1 Coagulation Factor Ii Receptor Thrombin Receptor |
| Database Links | Reactome: R-HSA-140875 Reactome: R-HSA-375276 Reactome: R-HSA-416476 Reactome: R-HSA-456926 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Proteinase-Activated Receptor 1 antibody Anti-Par-1 antibody Anti-Coagulation Factor Ii Receptor antibody Anti-Thrombin Receptor antibody Anti-F2R antibody Anti-CF2R antibody Anti-PAR1 antibody Anti-TR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
相關信息
![Anti-14-3-3 beta/Theta antibody (1-100) [S1MR] (STJ11103651)](http://y1.yzimgs.com/uploads/465546/2024520-20551366.png?imageView2/2/w/200/h/200)
- 細胞培養玄學-MRC-5細胞 2025-01-07
- Ocean NanoTech定製的詳細步驟 2021-10-31
- click chemistry tools數據結果比... 2021-10-31
- LaysanBio代理商相關文獻資料2020 2021-10-31
- Abbiotec代理的產品得到重複驗證2020 2021-10-31
- zyagen Laboratories代理的產品得到... 2021-06-20
- Toxin Technologies代理商相關文獻資... 2021-03-14
- 熱烈祝賀91麻豆福利视频网生物正式代理biocolor公司試劑產品... 2021-03-14
- 熱烈祝賀91麻豆福利视频网生物正式代理cytognos公司試劑產品... 2021-03-14
- Gelest代理的產品得到重複驗證2020 2021-03-14
