Anti-FAS antibody (C-Term) [4C3-G7-B7-H5] (STJ99086) STJ99086|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-FAS antibody (C-Term) [4C3-G7-B7-H5] (STJ99086)
產品型號：STJ99086
產品廠商：ST john's laboratory
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Anti-FAS antibody (C-Term) [4C3-G7-B7-H5] (STJ99086)

詳情介紹：

Host:	Mouse
Applications:	WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-Tumor necrosis factor receptor superfamily member 6 (C-Term) is suitable for use in Western Blot research applications.

Clonality:	Monoclonal
Clone ID:	4C3-G7-B7-H5
Conjugation:	Unconjugated
Isotype:	IgG1
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FAS
Gene ID:	355
Uniprot ID:	TNR6_HUMAN
Immunogen Region:	C-Term
Specificity:	This antibody detects endogenous levels of FAS (C-terminus) and does not cross-react with related proteins.
Immunogen:	Purified recombinant human FAS (C-terminus) protein fragments expressed in E.coli.

Post Translational Modifications	(Microbial infection) Glycosylated at Arg-250 by enteropathogenic E.coli protein NleB1: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions. Palmitoylated. Palmitoylation by ZDHHC7 prevents the lysosomal degradation of FAS regulating its expression at the plasma membrane. N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
Function	Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
Protein Name	Tumor Necrosis Factor Receptor Superfamily Member 6 Apo-1 Antigen Apoptosis-Mediating Surface Antigen Fas Faslg Receptor Cd Antigen Cd95
Database Links	Reactome: R-HSA-140534 Reactome: R-HSA-3371378 Reactome: R-HSA-5213460 Reactome: R-HSA-5218900 Reactome: R-HSA-6803211 Reactome: R-HSA-69416 Reactome: R-HSA-75157
Cellular Localisation	Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Membrane Raft Isoform 2: Secreted Isoform 3: Secreted Isoform 4: Secreted Isoform 5: Secreted Isoform 6: Secreted
Alternative Antibody Names	Anti-Tumor Necrosis Factor Receptor Superfamily Member 6 antibody Anti-Apo-1 Antigen antibody Anti-Apoptosis-Mediating Surface Antigen Fas antibody Anti-Faslg Receptor antibody Anti-Cd Antigen Cd95 antibody Anti-FAS antibody Anti-APT1 antibody Anti-FAS1 antibody Anti-TNFRSF6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-FAS antibody (C-Term) [4C3-G7-B7-H5] (STJ99086)