Anti-CDH1 antibody (C-Term) [M533] (STJA0005283) STJA0005283-100|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-CDH1 antibody (C-Term) [M533] (STJA0005283)
產品型號：STJA0005283-100
產品廠商：ST john's laboratory
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簡單介紹：

Anti-CDH1 antibody (C-Term) [M533] (STJA0005283)

詳情介紹：

Host:	Mouse
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-E-Cadherin (C-Term) is suitable for use in Western Blot research applications.

Clonality:	Monoclonal
Clone ID:	M533
Conjugation:	Unconjugated
Isotype:	IgG1
Formulation:	PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Purification:	Protein G Purified
Dilution Range:	WB 1:250 IHC ICC IP
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	Cdh1
Gene ID:	12550
Uniprot ID:	CADH1_MOUSE
Immunogen Region:	C-Term
Specificity:	The E-cadherin antibody detects a 120 kDa* protein corresponding to endogenous E-Cadherin expressed in human A431 cells.
Immunogen:	Clone (M533) was generated from a mouse recombinant E-Cadherin protein containing amino acids in the C-terminal region. This sequence is highly conserved in human and rat E-cadherin.

Tissue Specificity	Expressed in inner and outer pillar cells of the organ of Corti (at protein level). Non-neural epithelial tissues.
Post Translational Modifications	During apoptosis or with calcium influx, cleaved by a membrane-bound metalloproteinase (ADAM10), PS1/gamma-secretase and caspase-3. Processing by the metalloproteinase, induced by calcium influx, causes disruption of cell-cell adhesion and the subsequent release of beta-catenin into the cytoplasm. The residual membrane-tethered cleavage product is rapidly degraded via an intracellular proteolytic pathway. Cleavage by caspase-3 releases the cytoplasmic tail resulting in disintegration of the actin microfilament system. The gamma-secretase-mediated cleavage promotes disassembly of adherens junctions. During development of the cochlear organ of Corti, cleavage by ADAM10 at adherens junctions promotes pillar cell separation. O-glycosylated. O-manosylated by TMTC1, TMTC2, TMTC3 or TMTC4. Ser-287 and Thr-511 are O-manosylated by TMTC2 or TMTC4 but not TMTC1 or TMTC3. N-glycosylation at Asn-639 is essential for expression, folding and trafficking. Addition of bisecting N-acetylglucosamine by MGAT3 modulates its cell membrane locations. Ubiquitinated by a SCF complex containing SKP2, which requires prior phosphorylation by CK1/CSNK1A1. Ubiquitinated by CBLL1/HAKAI, requires prior phosphorylation at Tyr-756.
Function	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells.cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. (Microbial infection) Does not function as a receptor for L.monocytogenes internalin A (InlA).mutating a single surface-exposed residue confers receptor activity to this protein and promotes uptake of the bacteria.
Protein Name	Cadherin-1 Arc-1 Epithelial Cadherin E-Cadherin Uvomorulin Cd Antigen Cd324 Cleaved Into - E-Cad/Ctf1 - E-Cad/Ctf2 - E-Cad/Ctf3
Database Links	Reactome: R-MMU-1474228 Reactome: -MMU-216083 Reactome: -MMU-351906 Reactome: -MMU-418990 Reactome: -MMU-5626467
Cellular Localisation	Cell Junction Adherens Junction Cell Membrane Single-Pass Type I Membrane Protein Endosome Golgi Apparatus Trans-Golgi Network Colocalizes With Dlgap5 At Sites Of Cell-Cell Contact In Intestinal Epithelial Cells Anchored To Actin Microfilaments Through Association With Alpha- Beta- And Gamma-Catenin Sequential Proteolysis Induced By Apoptosis Or Calcium Influx Results In Translocations From Sites Of Cell-Cell Contact To The Cytoplasm Colocalizes With Rab11a Endosomes During Its Transport From The Golgi Apparatus To The Plasma Membrane
Alternative Antibody Names	Anti-Cadherin-1 antibody Anti-Arc-1 antibody Anti-Epithelial Cadherin antibody Anti-E-Cadherin antibody Anti-Uvomorulin antibody Anti-Cd Antigen Cd324 Cleaved Into - E-Cad/Ctf1 - E-Cad/Ctf2 - E-Cad/Ctf3 antibody Anti-Cdh1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-CDH1 antibody (C-Term) [M533] (STJA0005283)