Mouse XRCC5 (X-Ray Repair Cross Complementing 5) Sandwich ELISA Kit Ready-To-Use (STJE0019521) STJE0019521|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

所在位置: 首頁> 產品目錄> S類> ST john's laboratory>

查看大圖

產品名稱：Mouse XRCC5 (X-Ray Repair Cross Complementing 5) Sandwich ELISA Kit Ready-To-Use (STJE0019521)
產品型號：STJE0019521
產品廠商：ST john's laboratory
產品文檔：

你添加了1件商品查看購物車

簡單介紹：

Mouse XRCC5 (X-Ray Repair Cross Complementing 5) Sandwich ELISA Kit Ready-To-Use (STJE0019521)

詳情介紹：

Applications:	ELISA
Reactivity:	Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.072ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This XRCC5 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	Xrcc5
Gene ID:	22596
Uniprot ID:	XRCC5_MOUSE
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates or other biological fluids.

Tissue Specificity
Post Translational Modifications	ADP-ribosylated by PARP3. Phosphorylated on serine residues. Phosphorylation by PRKDC may enhance helicase activity. Sumoylated. Ubiquitinated by RNF8 via 'Lys-48'-linked ubiquitination following DNA damage, leading to its degradation and removal from DNA damage sites. Ubiquitinated by RNF138, leading to remove the Ku complex from DNA breaks.
Function	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocations. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection. Binding to DNA may be mediated by XRCC6. The XRCC5-XRRC6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. The XRCC5-XRRC6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription. In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression. As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome. Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.
Protein Name	X-Ray Repair Cross-Complementing Protein 5 Atp-Dependent Dna Helicase 2 Subunit 2 Atp-Dependent Dna Helicase Ii 80 Kda Subunit Ctc Box-Binding Factor 85 Kda Subunit Ctc85 Ctcbf Dna Repair Protein Xrcc5 Ku Autoantigen Protein P86 Homolog Ku80 Nuclear Factor Iv
Database Links	Reactome: R-MMU-5693571 Reactome: -MMU-6798695
Cellular Localisation	Nucleus Nucleolus Chromosome
Alternative ELISA Names	X-Ray Repair Cross-Complementing Protein 5 ELISA kit Atp-Dependent Dna Helicase 2 Subunit 2 ELISA kit Atp-Dependent Dna Helicase Ii 80 Kda Subunit ELISA kit Ctc Box-Binding Factor 85 Kda Subunit ELISA kit Ctc85 ELISA kit Ctcbf ELISA kit Dna Repair Protein Xrcc5 ELISA kit Ku Autoantigen Protein P86 Homolog ELISA kit Ku80 ELISA kit Nuclear Factor Iv ELISA kit Xrcc5 ELISA kit G22p2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

姓名：

電話：

您的需求：

產品名稱：Mouse XRCC5 (X-Ray Repair Cross Complementing 5) Sandwich ELISA Kit Ready-To-Use (STJE0019521)