Anti-FBXW7 antibody (N-Term) (STJA0005733) STJA0005733-100|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-FBXW7 antibody (N-Term) (STJA0005733)
產品型號：STJA0005733-100
產品廠商：ST john's laboratory
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簡單介紹：

Anti-FBXW7 antibody (N-Term) (STJA0005733)

詳情介紹：

Host:	Rabbit
Applications:	WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-FBXW7 (N-Term) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS + 0.02% NaN3
Purification:	Antigen Affinity Purified
Dilution Range:	WB 1:500-1:1000 IHC ICC IP
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FBXW7
Gene ID:	55294
Uniprot ID:	FBXW7_HUMAN
Immunogen Region:	N-Term
Specificity:	Reacts with the N terminus of the 69 kDa isoform of the hCdc4 protein
Immunogen:	Synthetic peptide corresponding to amino acids from the N-terminal region of human Cdc4 protein

Post Translational Modifications	Phosphorylation at Thr-205 promotes interaction with PIN1, leading to disrupt FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation. Phosphorylated by ATM at Ser-26 in response to DNA damage, promoting recruitment to DNA damage sites and 'Lys-63'-linked ubiquitination of phosphorylated XRCC4. Ubiquitinated: autoubiquitinates following phosphorylation at Thr-205 and subsequent interaction with PIN1. Ubiquitination leads to its proteasomal degradation.
Function	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter brings them to the SCF complex for ubiquitination. Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NFE2L1, NOTCH2, MCL1, MLST8, RICTOR, and probably PSEN1. Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation. Involved in bone homeostasis and negative regulation of osteoclast differentiation. Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1.CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination. Also able to promote 'Lys-63'-linked ubiquitination in response to DNA damage. The SCF(FBXW7) complex facilitates double-strand break repair following phosphorylation by ATM: phosphorylation promotes localization to sites of double-strand breaks and 'Lys-63'-linked ubiquitination of phosphorylated XRCC4, enhancing DNA non-homologous end joining.
Protein Name	F-Box/Wd Repeat-Containing Protein 7 Archipelago Homolog Hago F-Box And Wd-40 Domain-Containing Protein 7 F-Box Protein Fbx30 Sel-10 Hcdc4
Database Links	Reactome: R-HSA-2122947 Reactome: R-HSA-2644606 Reactome: R-HSA-2644607 Reactome: R-HSA-2894862 Reactome: R-HSA-390471 Reactome: R-HSA-8939902 Q969H0-1 Reactome: R-HSA-8951664 Reactome: R-HSA-9604323 Reactome: R-HSA-983168
Cellular Localisation	Isoform 1: Nucleus Nucleoplasm Chromosome Localizes To Site Of Double-Strand Breaks Following Phosphorylation By Atm Isoform 2: Cytoplasm Isoform 3: Nucleus Nucleolus
Alternative Antibody Names	Anti-F-Box/Wd Repeat-Containing Protein 7 antibody Anti-Archipelago Homolog antibody Anti-Hago antibody Anti-F-Box And Wd-40 Domain-Containing Protein 7 antibody Anti-F-Box Protein Fbx30 antibody Anti-Sel-10 antibody Anti-Hcdc4 antibody Anti-FBXW7 antibody Anti-FBW7 antibody Anti-FBX30 antibody Anti-SEL10 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-FBXW7 antibody (N-Term) (STJA0005733)