Anti-FBXW8 antibody (500-598) (STJ11100092) STJ11100092|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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Anti-FBXW8 antibody (500-598) (STJ11100092)

詳情介紹：

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-FBXW8 (500-598) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FBXW8
Gene ID:	26259
Uniprot ID:	FBXW8_HUMAN
Immunogen Region:	500-598
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 500-598 of human FBXW8 (NP_699179.2).
Immunogen Sequence:	WDYRMNQKLWEVYSGHPVQH ISFSSHSLITANVPYQTVMR NADLDSFTTHRRHRGLIRAY EFAVDQLAFQSPLPVCRSSC DAMATHYYDLALAFPYNHV

Function	Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation. Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions.
Protein Name	F-Box/Wd Repeat-Containing Protein 8 F-Box And Wd-40 Domain-Containing Protein 8 F-Box Only Protein 29
Database Links	Reactome: R-HSA-8951664 Reactome: R-HSA-983168
Cellular Localisation	Cytoplasm Perinuclear Region Golgi Apparatus Colocalizes With Cul7 At The Golgi Apparatus In Neurons
Alternative Antibody Names	Anti-F-Box/Wd Repeat-Containing Protein 8 antibody Anti-F-Box And Wd-40 Domain-Containing Protein 8 antibody Anti-F-Box Only Protein 29 antibody Anti-FBXW8 antibody Anti-FBW6 antibody Anti-FBW8 antibody Anti-FBX29 antibody Anti-FBXO29 antibody Anti-FBXW6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-FBXW8 antibody (500-598) (STJ11100092)