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Anti-FEM1C antibody (STJA0009484) STJA0009484|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司
產品詳情

  • 產品名稱：Anti-FEM1C antibody (STJA0009484)

  • 產品型號：STJA0009484
  • 產品廠商：ST john's laboratory
  • 產品文檔：
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簡單介紹：
Anti-FEM1C antibody (STJA0009484)
詳情介紹：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Protein fem-1 homolog C is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FEM1C
Gene ID: 56929
Uniprot ID: FEM1C_HUMAN
Specificity: This antibody detects endogenous levels of FEM1C at Human, Mouse
Immunogen: Synthesized peptide derived from human FEM1C
Function Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1C) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation. The CRL2(FEM1C) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding. Promotes ubiquitination and degradation of SLBP.
Protein Name Protein Fem-1 Homolog C
Fem1c
Fem1-Gamma
Database Links Reactome: R-HSA-8951664
Alternative Antibody Names Anti-Protein Fem-1 Homolog C antibody
Anti-Fem1c antibody
Anti-Fem1-Gamma antibody
Anti-FEM1C antibody
Anti-KIAA1785 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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