產品詳情
簡單介紹：
Anti-FEN1 antibody (250-350) [S6MR] (STJ11102406)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit monoclonal antibody anti-FEN1 (250-350) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: | Monoclonal |
| Clone ID: | S6MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 IHC-P 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FEN1 |
| Gene ID: | 2237 |
| Uniprot ID: | FEN1_HUMAN |
| Immunogen Region: | 250-350 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human FEN-1 (P39748). |
| Immunogen Sequence: | IQKHKSIEEIVRRLDPNKYP VPENWLHKEAHQLFLEPEVL DPESVELKWSEPNEEELIKF MCGEKQFSEERIRSGVKRLS KSRQGSTQGRLDDFFKVTGS L |
| Post Translational Modifications | Acetylated by EP300. Acetylation inhibits both endonuclease and exonuclease activity. Acetylation also reduces DNA-binding activity but does not affect interaction with PCNA or EP300. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma. Phosphorylation at Ser-187 by CDK2 occurs during late S-phase and results in dissociation from PCNA. Methylation at Arg-192 by PRMT5 impedes Ser-187 phosphorylation and increases interaction with PCNA. |
| Function | Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. |
| Protein Name | Flap Endonuclease 1 Fen-1 Dnase Iv Flap Structure-Specific Endonuclease 1 Maturation Factor 1 Mf1 Hfen-1 |
| Database Links | Reactome: R-HSA-110362 Reactome: R-HSA-162594 Reactome: R-HSA-174437 Reactome: R-HSA-5651801 Reactome: R-HSA-5685939 Reactome: R-HSA-69166 |
| Cellular Localisation | Isoform 1: Nucleus Nucleolus Nucleus Nucleoplasm Resides Mostly In The Nucleoli And Relocalizes To The Nucleoplasm Upon Dna Damage Isoform Fenmit: Mitochondrion |
| Alternative Antibody Names | Anti-Flap Endonuclease 1 antibody Anti-Fen-1 antibody Anti-Dnase Iv antibody Anti-Flap Structure-Specific Endonuclease 1 antibody Anti-Maturation Factor 1 antibody Anti-Mf1 antibody Anti-Hfen-1 antibody Anti-FEN1 antibody Anti-RAD2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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