Anti-FFAR2 antibody (271-320 aa) (STJ93387) STJ93387|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-FFAR2 antibody (271-320 aa) (STJ93387)
產品型號：STJ93387
產品廠商：ST john's laboratory
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Anti-FFAR2 antibody (271-320 aa) (STJ93387)

詳情介紹：

Host:	Rabbit
Applications:	IF/ELISA
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Free fatty acid receptor 2 (271-320 aa) is suitable for use in Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	IF 1:200-1:1000 ELISA 1:5000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FFAR2
Gene ID:	2867
Uniprot ID:	FFAR2_HUMAN
Immunogen Region:	271-320 aa
Specificity:	GPR43 Polyclonal Antibody detects endogenous levels of GPR43 protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human FFAR2 at the amino acid range 271-320

Function	G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes. Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably acetate, propionate and butyrate. Exhibits a SCFA-independent constitutive G protein-coupled receptor activity.
Protein Name	Free Fatty Acid Receptor 2 G-Protein Coupled Receptor 43
Database Links	Reactome: R-HSA-416476 Reactome: R-HSA-444209
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein
Alternative Antibody Names	Anti-Free Fatty Acid Receptor 2 antibody Anti-G-Protein Coupled Receptor 43 antibody Anti-FFAR2 antibody Anti-FFA2 antibody Anti-GPCR43 antibody Anti-GPR43 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-FFAR2 antibody (271-320 aa) (STJ93387)