Anti-FGFR3 antibody (1-100) [S0MR] (STJ11101590) STJ11101590|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-FGFR3 antibody (1-100) [S0MR] (STJ11101590)
產品型號：STJ11101590
產品廠商：ST john's laboratory
產品文檔：

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簡單介紹：

Anti-FGFR3 antibody (1-100) [S0MR] (STJ11101590)

詳情介紹：

Host:	Rabbit
Applications:	WB/IHC
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-FGFR3 (1-100) is suitable for use in Western Blot and Immunohistochemistry research applications.

Clonality:	Monoclonal
Clone ID:	S0MR
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IHC-P 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FGFR3
Gene ID:	2261
Uniprot ID:	FGFR3_HUMAN
Immunogen Region:	1-100
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FGFR3 (P22607).
Immunogen Sequence:	MGAPACALALCVAVAIVAGA SSESLGTEQRVVGRAAEVPG PEPGQQEQLVFGSGDAVELS CPPPGGGPMGPTVWVKDGTG LVPSERVLVGPQRLQVLNAS

Tissue Specificity	Expressed in brain, kidney and testis. Very low or no expression in spleen, heart, and muscle. In 20- to 22-week old fetuses it is expressed at high level in kidney, lung, small intestine and brain, and to a lower degree in spleen, liver, and muscle. Isoform 2 is detected in epithelial cells. Isoform 1 is not detected in epithelial cells. Isoform 1 and isoform 2 are detected in fibroblastic cells.
Post Translational Modifications	Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer. Phosphorylation at Tyr-724 is essential for stimulation of cell proliferation and activation of PIK3R1, STAT1 and MAP kinase signaling. Phosphorylation at Tyr-760 is required for interaction with PIK3R1 and PLCG1. Ubiquitinated. Is rapidly ubiquitinated after ligand binding and autophosphorylation, leading to receptor internalization and degradation. Subject to both proteasomal and lysosomal degradation. N-glycosylated in the endoplasmic reticulum. The N-glycan chains undergo further maturation to an Endo H-resistant form in the Golgi apparatus.
Function	Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling.
Protein Name	Fibroblast Growth Factor Receptor 3 Fgfr-3 Cd Antigen Cd333
Database Links	Reactome: R-HSA-109704 Reactome: R-HSA-1257604 Reactome: R-HSA-1839130 Reactome: R-HSA-190371 P22607-2 Reactome: R-HSA-190372 P22607-1 Reactome: R-HSA-2033515 Reactome: R-HSA-2219530 Reactome: R-HSA-5654227 Reactome: R-HSA-5654704 Reactome: R-HSA-5654706 Reactome: R-HSA-5654710 Reactome: R-HSA-5654732 Reactome: R-HSA-5655332 Reactome: R-HSA-5673001 Reactome: R-HSA-6811558 Reactome: R-HSA-8853334
Cellular Localisation	Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Cytoplasmic Vesicle Endoplasmic Reticulum The Activated Receptor Is Rapidly Internalized And Degraded Detected In Intracellular Vesicles After Internalization Of The Autophosphorylated Receptor Isoform 2: Cell Membrane Isoform 3: Secreted Isoform 4: Cell Membrane
Alternative Antibody Names	Anti-Fibroblast Growth Factor Receptor 3 antibody Anti-Fgfr-3 antibody Anti-Cd Antigen Cd333 antibody Anti-FGFR3 antibody Anti-JTK4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-FGFR3 antibody (1-100) [S0MR] (STJ11101590)