產品詳情
簡單介紹：
Anti-FHL2 antibody (50-260) [S9MR] (STJ11101919)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit monoclonal antibody anti-FHL2 (50-260) is suitable for use in Western Blot research applications. |
| Clonality: | Monoclonal |
| Clone ID: | S9MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FHL2 |
| Gene ID: | 2274 |
| Uniprot ID: | FHL2_HUMAN |
| Immunogen Region: | 50-260 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-260 of human FHL2 (Q14192). |
| Immunogen Sequence: | DCKDLSYKDRHWHEACFHCS QCRNSLVDKPFAAKEDQLLC TDCYSNEYSSKCQECKKTIM PGTRKMEYKGSSWHETCFIC HRCQQPIGTKSFIPKDNQNF CVPCYEKQHAMQCVQCKKPI TTGGVTYREQPWHKECFVCT ACRKQLSGQRFTARDDFAYC LNCFCDLYAKKCAGCTNPIS GLGGTKYISFEERQWHNDCF NCKKCSLSLVG |
| Tissue Specificity | Expressed in skeletal muscle and heart. |
| Function | May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes. |
| Protein Name | Four And A Half Lim Domains Protein 2 Fhl-2 Lim Domain Protein Dral Skeletal Muscle Lim-Protein 3 Slim-3 |
| Database Links | Reactome: R-HSA-1989781 |
| Cellular Localisation | Cytoplasm Nucleus Myofibril Sarcomere Z Line |
| Alternative Antibody Names | Anti-Four And A Half Lim Domains Protein 2 antibody Anti-Fhl-2 antibody Anti-Lim Domain Protein Dral antibody Anti-Skeletal Muscle Lim-Protein 3 antibody Anti-Slim-3 antibody Anti-FHL2 antibody Anti-DRAL antibody Anti-SLIM3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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