Anti-FKBP5 antibody (350-457) [S1MR] (STJ11102421) STJ11102421|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-FKBP5 antibody (350-457) [S1MR] (STJ11102421)
產品型號：STJ11102421
產品廠商：ST john's laboratory
產品文檔：

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簡單介紹：

Anti-FKBP5 antibody (350-457) [S1MR] (STJ11102421)

詳情介紹：

Host:	Rabbit
Applications:	WB/IHC
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-FKBP51 (350-457) is suitable for use in Western Blot and Immunohistochemistry research applications.

Clonality:	Monoclonal
Clone ID:	S1MR
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IHC-P 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FKBP5
Gene ID:	2289
Uniprot ID:	FKBP5_HUMAN
Immunogen Region:	350-457
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 350-457 of human FKBP51/FKBP5 (Q13451).
Immunogen Sequence:	NEKGLYRRGEAQLLMNEFES AKGDFEKVLEVNPQNKAARL QISMCQKKAKEHNERDRRIY ANMFKKFAEQDAKEEANKAM GKKTSEGVTNEKGTDSQAME EEKPEGHV

Tissue Specificity	Widely expressed, enriched in testis compared to other tissues.
Post Translational Modifications	Acetylation impairs ability to promote interaction between Akt/AKT1 and PHLPP1. Deacetylation by SIRT7 promotes interaction between Akt/AKT1 and PHLPP1, leading to suppress Akt/AKT1 activation.
Function	Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1. Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappaB activation, and IFN production.
Protein Name	Peptidyl-Prolyl Cis-Trans Isomerase Fkbp5 Ppiase Fkbp5 51 Kda Fk506-Binding Protein 51 Kda Fkbp Fkbp-51 54 Kda Progesterone Receptor-Associated Immunophilin Androgen-Regulated Protein 6 Ff1 Antigen Fk506-Binding Protein 5 Fkbp-5 Fkbp54 P54 Hsp90-Binding Immunophilin Rotamase
Database Links	Reactome: R-HSA-3371497 Reactome: R-HSA-8939211 Reactome: R-HSA-9022699
Cellular Localisation	Cytoplasm Nucleus
Alternative Antibody Names	Anti-Peptidyl-Prolyl Cis-Trans Isomerase Fkbp5 antibody Anti-Ppiase Fkbp5 antibody Anti-51 Kda Fk506-Binding Protein antibody Anti-51 Kda Fkbp antibody Anti-Fkbp-51 antibody Anti-54 Kda Progesterone Receptor-Associated Immunophilin antibody Anti-Androgen-Regulated Protein 6 antibody Anti-Ff1 Antigen antibody Anti-Fk506-Binding Protein 5 antibody Anti-Fkbp-5 antibody Anti-Fkbp54 antibody Anti-P54 antibody Anti-Hsp90-Binding Immunophilin antibody Anti-Rotamase antibody Anti-FKBP5 antibody Anti-AIG6 antibody Anti-FKBP51 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-FKBP5 antibody (350-457) [S1MR] (STJ11102421)