產品詳情
簡單介紹：
Anti-FLG2 antibody (402-452 aa) (STJ195486)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Filaggrin-2 (402-452 aa) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FLG2 |
| Gene ID: | 388698 |
| Uniprot ID: | FILA2_HUMAN |
| Immunogen Region: | 402-452 aa |
| Specificity: | This antibody detects endogenous levels of FILA2 at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human FILA2 at the amino acid range 402-452 |
| Post Translational Modifications | Deiminated by PADI1, PADI2 or PADI3 in vitro. The deiminated form is degraded by calpain-1/CAPN1 more quickly and into shorter peptides than the intact protein. May be processed by calpain-1/CAPN1 in the uppermost epidermal layers. |
| Function | Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis. |
| Protein Name | Filaggrin-2 Flg-2 Intermediate Filament-Associated And Psoriasis-Susceptibility Protein Ifapsoriasin |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Cytoplasm Cytoplasmic Granule In The Stratum Corneum Of The Epidermis Dispersed Diffusely Throughout The Cytoplasm While In The Stratum Granulosum Localized Within Keratohyalin Granules In Granular Keratinocytes And In Lower Corneocytes Colocalizes With Calpain-1/Capn1 |
| Alternative Antibody Names | Anti-Filaggrin-2 antibody Anti-Flg-2 antibody Anti-Intermediate Filament-Associated And Psoriasis-Susceptibility Protein antibody Anti-Ifapsoriasin antibody Anti-FLG2 antibody Anti-IFPS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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