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Anti-FLRT3 antibody (STJ192077) STJ192077|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司
產品詳情

  • 產品名稱：Anti-FLRT3 antibody (STJ192077)

  • 產品型號：STJ192077
  • 產品廠商：ST john's laboratory
  • 產品文檔：
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簡單介紹：
Anti-FLRT3 antibody (STJ192077)
詳情介紹：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Leucine-rich repeat transmembrane protein FLRT3 is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FLRT3
Gene ID: 23767
Uniprot ID: FLRT3_HUMAN
Specificity: FLRT3 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from part of the human protein
Post Translational Modifications N-glycosylated. Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease.
Function Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina. Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members. Promotes neurite outgrowth (in vitro). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development.
Protein Name Leucine-Rich Repeat Transmembrane Protein Flrt3
Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 3
Database Links Reactome: R-HSA-376176
Reactome: R-HSA-5654687
Cellular Localisation Cell Membrane
Single-Pass Membrane Protein
Endoplasmic Reticulum Membrane
Cell Junction
Focal Adhesion
Secreted
Cell Projection
Axon
Growth Cone Membrane
Detected On Dendritic Punctae That Colocalize In Part With Glutamaergic Synapses
But Not With Gabaergic Synapses
Proteolytic Cleavage In The Juxtamembrane Region Gives Rise To A Shedded Ectodomain
Alternative Antibody Names Anti-Leucine-Rich Repeat Transmembrane Protein Flrt3 antibody
Anti-Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 3 antibody
Anti-FLRT3 antibody
Anti-KIAA1469 antibody
Anti-UNQ856 antibody
Anti-PRO1865 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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