產品詳情
簡單介紹：
Anti-FMO2 antibody (210-470) (STJ115916)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-FMO2 (210-470) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FMO2 |
| Gene ID: | 2327 |
| Uniprot ID: | FMO2_HUMAN |
| Immunogen Region: | 210-470 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 210-470 of human FMO2 (NP_001451.2). |
| Immunogen Sequence: | VFISTRHGTWVMSRISEDGY PWDSVFHTRFRSMLRNVLPR TAVKWMIEQQMNRWFNHENY GLEPQNKYIMKEPVLNDDVP SRLLCGAIKVKSTVKELTET SAIFEDGTVEENIDVIIFAT GYSFSFPFLEDSLVKVENNM VSLYKYIFPAHLDKSTLACI GLIQPLGSIFPTAELQARWV TRVFKGLCSLPSERTMMMDI IKRNEKRIDLFGESQSQTLQ TNYVDYLDELALEIGAKPD |
| Tissue Specificity | Expressed in lung (at protein level). Expressed predominantly in lung, and at a much lesser extent in kidney. Also expressed in fetal lung, but not in liver, kidney and brain. |
| Function | Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation. Specifically catalyzes S-oxygenation of sulfur derived compounds such as thioureas-derived compounds, thioetherorganophosphates to their sulfenic acid. In vitro, catalyzes S-oxygenation of the second-line antitubercular drugs thiacetazone (TAZ) and ethionamide (ETA), forming a sulfinic acid and a carbodiimide via a postulated sulfenic acid intermediate. Also catalyzes S-oxygenation of the thioether-containing organophosphate insecticides, phorate and disulfoton. |
| Protein Name | Flavin-Containing Monooxygenase 2 Dimethylaniline Oxidase 2 Fmo 1b1 Pulmonary Flavin-Containing Monooxygenase 2 Fmo 2 |
| Database Links | Reactome: R-HSA-217271 |
| Cellular Localisation | Microsome Membrane Single-Pass Membrane Protein Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Flavin-Containing Monooxygenase 2 antibody Anti-Dimethylaniline Oxidase 2 antibody Anti-Fmo 1b1 antibody Anti-Pulmonary Flavin-Containing Monooxygenase 2 antibody Anti-Fmo 2 antibody Anti-FMO2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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