產品詳情
簡單介紹：
Anti-FNBP1 antibody (STJA0008714)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Formin-binding protein 1 is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FNBP1 |
| Gene ID: | 23048 |
| Uniprot ID: | FNBP1_HUMAN |
| Specificity: | This antibody detects endogenous levels of FBP17 at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human FBP17 |
| Function | May act as a link between RND2 signaling and regulation of the actin cytoskeleton. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. |
| Protein Name | Formin-Binding Protein 1 Formin-Binding Protein 17 Hfbp17 |
| Database Links | Reactome: R-HSA-8856828 Reactome: R-HSA-9013148 Reactome: R-HSA-9013406 Reactome: R-HSA-9013409 Reactome: R-HSA-9696270 |
| Cellular Localisation | Cytoplasm Cytoskeleton Cell Cortex Lysosome Cytoplasmic Vesicle Cell Membrane Peripheral Membrane Protein Cytoplasmic Side Membrane Clathrin-Coated Pit Enriched In Cortical Regions Coincident With F-Actin Also Localizes To Endocytic Vesicles And Lysosomes |
| Alternative Antibody Names | Anti-Formin-Binding Protein 1 antibody Anti-Formin-Binding Protein 17 antibody Anti-Hfbp17 antibody Anti-FNBP1 antibody Anti-FBP17 antibody Anti-KIAA0554 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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