產品詳情
簡單介紹：
Anti-FOXM1 antibody (190-270 aa) (STJ190208)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Forkhead box protein M1 (190-270 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FOXM1 |
| Gene ID: | 2305 |
| Uniprot ID: | FOXM1_HUMAN |
| Immunogen Region: | 190-270 aa |
| Specificity: | FOXM1 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 190-270 |
| Post Translational Modifications | Phosphorylated in M (mitotic) phase. Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair. Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators. |
| Function | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Also plays a role in DNA break repair, participating in the DNA damage checkpoint response. Promotes transcription of PHB2. |
| Protein Name | Forkhead Box Protein M1 Forkhead-Related Protein Fkhl16 Hepatocyte Nuclear Factor 3 Forkhead Homolog 11 Hfh-11 Hnf-3/Fork-Head Homolog 11 M-Phase Phosphoprotein 2 Mpm-2 Reactive Phosphoprotein 2 Transcription Factor Trident Winged-Helix Factor From Ins-1 Cells |
| Database Links | Reactome: R-HSA-156711 Reactome: R-HSA-69273 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Forkhead Box Protein M1 antibody Anti-Forkhead-Related Protein Fkhl16 antibody Anti-Hepatocyte Nuclear Factor 3 Forkhead Homolog 11 antibody Anti-Hfh-11 antibody Anti-Hnf-3/Fork-Head Homolog 11 antibody Anti-M-Phase Phosphoprotein 2 antibody Anti-Mpm-2 Reactive Phosphoprotein 2 antibody Anti-Transcription Factor Trident antibody Anti-Winged-Helix Factor From Ins-1 Cells antibody Anti-FOXM1 antibody Anti-FKHL16 antibody Anti-HFH11 antibody Anti-MPP2 antibody Anti-WIN antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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