產品詳情
簡單介紹：
Anti-FSCN1 antibody (250-350 aa) [ABT-FASN] (STJ196833)
詳情介紹：
| Host: | Mouse |
| Applications: | IHC/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-Fascin (250-350 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: | Monoclonal |
| Clone ID: | ABT-FASN |
| Conjugation: | Unconjugated |
| Isotype: | IgG1k |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range: | IHC-P 1:100-500 WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FSCN1 |
| Gene ID: | 6624 |
| Uniprot ID: | FSCN1_HUMAN |
| Immunogen Region: | 250-350 aa |
| Specificity: | This antibody detects endogenous levels of human Fascin. Heat-induced epitope retrievals (HIER) TRIS-EDTA of pH8.0 was highly recommended as antigen repair method in paraffin section |
| Immunogen: | Synthesized peptide derived from the human Fascin at the amino acid range 250-350 |
| Post Translational Modifications | Phosphorylation at Ser-39 inhibits actin-binding. Phosphorylation is required for the reorganization of the actin cytoskeleton in response to NGF. |
| Function | Actin-binding protein that contains 2 major actin binding sites. Organizes filamentous actin into parallel bundles. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF. |
| Protein Name | Fascin 55 Kda Actin-Bundling Protein Singed-Like Protein P55 |
| Database Links | Reactome: R-HSA-6785807 |
| Cellular Localisation | Cytoplasm Cytosol Cell Cortex Cytoskeleton Stress Fiber Cell Projection Filopodium Invadopodium Microvillus Cell Junction Colocalized With Rufy3 And F-Actin At Filipodsia Of The Axonal Growth Cone Colocalized With Dbn1 And F-Actin At The Transitional Domain Of The Axonal Growth Cone |
| Alternative Antibody Names | Anti-Fascin antibody Anti-55 Kda Actin-Bundling Protein antibody Anti-Singed-Like Protein antibody Anti-P55 antibody Anti-FSCN1 antibody Anti-FAN1 antibody Anti-HSN antibody Anti-SNL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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