Anti-JAK2 antibody (933-1132) (STJ110007) STJ110007|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

所在位置: 首頁> 產品目錄> S類> ST john's laboratory>

查看大圖

產品名稱：Anti-JAK2 antibody (933-1132) (STJ110007)
產品型號：STJ110007
產品廠商：ST john's laboratory
產品文檔：

你添加了1件商品查看購物車

簡單介紹：

Anti-JAK2 antibody (933-1132) (STJ110007)

詳情介紹：

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-JAK2 (933-1132) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:100-1:500
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	JAK2
Gene ID:	3717
Uniprot ID:	JAK2_HUMAN
Immunogen Region:	933-1132
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 933-1132 of human JAK2 (NP_004963.1).
Immunogen Sequence:	PYGSLRDYLQKHKERIDHIK LLQYTSQICKGMEYLGTKRY IHRDLATRNILVENENRVKI GDFGLTKVLPQDKEYYKVKE PGESPIFWYAPESLTESKFS VASDVWSFGVVLYELFTYIE KSKSPPAEFMRMIGNDKQGQ MIVFHLIELLKNNGRLPRPD GCPDEIYMIMTECWNNNVNQ RPSFRDLALRVDQIRDNMAG

Tissue Specificity	Ubiquitously expressed throughout most tissues.
Post Translational Modifications	Autophosphorylated, leading to regulate its activity. Leptin promotes phosphorylation on tyrosine residues, including phosphorylation on Tyr-813. Autophosphorylation on Tyr-119 in response to EPO down-regulates its kinase activity. Autophosphorylation on Tyr-868, Tyr-966 and Tyr-972 in response to growth hormone (GH) are required for maximal kinase activity. Also phosphorylated by TEC. Phosphorylated on tyrosine residues in response to interferon gamma signaling. Phosphorylated on tyrosine residues in response to a signaling cascade that is activated by increased cellular retinol. Undergoes Notch-induced ubiquitination and subsequent proteasomal degradation which is mediated by ASB1 or ASB2, the substrate-recognition components of probable ECS E3 ubiquitin-protein ligase complexes.
Function	Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO).or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.
Protein Name	Tyrosine-Protein Kinase Jak2 Janus Kinase 2 Jak-2
Database Links	Reactome: R-HSA-1059683 Reactome: R-HSA-110056 Reactome: R-HSA-112411 Reactome: R-HSA-1170546 Reactome: R-HSA-1433557 Reactome: R-HSA-2586552 Reactome: R-HSA-3214858 Reactome: R-HSA-512988 Reactome: R-HSA-5673000 Reactome: R-HSA-5673001 Reactome: R-HSA-6785807 Reactome: R-HSA-6788467 Reactome: R-HSA-6802946 Reactome: R-HSA-6802952 Reactome: R-HSA-6802955 Reactome: R-HSA-69231 Reactome: R-HSA-877300 Reactome: R-HSA-877312 Reactome: R-HSA-8854691 Reactome: R-HSA-8984722 Reactome: R-HSA-9006335 Reactome: R-HSA-9020591 Reactome: R-HSA-9020933 Reactome: R-HSA-9020956 Reactome: R-HSA-9027276 Reactome: R-HSA-9027277 Reactome: R-HSA-9027283 Reactome: R-HSA-9027284 Reactome: R-HSA-912526 Reactome: R-HSA-9649948 Reactome: R-HSA-9656223 Reactome: R-HSA-9670439 Reactome: R-HSA-9674555 Reactome: R-HSA-9679191 Reactome: R-HSA-9705462 Reactome: R-HSA-9732724 Reactome: R-HSA-982772 Reactome: R-HSA-983231
Cellular Localisation	Endomembrane System Peripheral Membrane Protein Cytoplasm Nucleus
Alternative Antibody Names	Anti-Tyrosine-Protein Kinase Jak2 antibody Anti-Janus Kinase 2 antibody Anti-Jak-2 antibody Anti-JAK2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

姓名：

電話：

您的需求：

產品名稱：Anti-JAK2 antibody (933-1132) (STJ110007)