Anti-SHC1 antibody (360-373) (STJ110036) STJ110036|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-SHC1 antibody (360-373) (STJ110036)
產品型號：STJ110036
產品廠商：ST john's laboratory
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簡單介紹：

Anti-SHC1 antibody (360-373) (STJ110036)

詳情介紹：

Host:	Rabbit
Applications:	WB/IHC/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-SHC1 (360-373) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	SHC1
Gene ID:	6464
Uniprot ID:	SHC1_HUMAN
Immunogen Region:	360-373
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 360-373 of human SHC1 (NP_001189788.1).
Immunogen Sequence:	TTPGQYVLTGLQSG

Tissue Specificity	Widely expressed. Expressed in neural stem cells but absent in mature neurons.
Post Translational Modifications	Phosphorylated by activated epidermal growth factor receptor. Phosphorylated in response to FLT4 and KIT signaling. Isoform p46Shc and isoform p52Shc are phosphorylated on tyrosine residues of the Pro-rich domain. Isoform p66Shc is phosphorylated on Ser-36 by PRKCB upon treatment with insulin, hydrogen peroxide or irradiation with ultraviolet light. Tyrosine phosphorylated in response to FLT3 signaling. Tyrosine phosphorylated by activated PTK2B/PYK2. Tyrosine phosphorylated by ligand-activated ALK. Tyrosine phosphorylated by ligand-activated PDGFRB. Tyrosine phosphorylated by TEK/TIE2. May be tyrosine phosphorylated by activated PTK2/FAK1.tyrosine phosphorylation was seen in an astrocytoma biopsy, where PTK2/FAK1 kinase activity is high, but not in normal brain tissue. Isoform p52Shc dephosphorylation by PTPN2 may regulate interaction with GRB2.
Function	Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.
Protein Name	Shc-Transforming Protein 1 Shc-Transforming Protein 3 Shc-Transforming Protein A Src Homology 2 Domain-Containing-Transforming Protein C1 Sh2 Domain Protein C1
Database Links	Reactome: R-HSA-1236382 Reactome: R-HSA-1250196 Reactome: R-HSA-1250347 Reactome: R-HSA-167044 Reactome: R-HSA-180336 Reactome: R-HSA-201556 Reactome: R-HSA-210993 Reactome: R-HSA-2424491 P29353-2 Reactome: R-HSA-2428933 Reactome: R-HSA-2730905 P29353-2 Reactome: R-HSA-2871796 P29353-2 Reactome: R-HSA-2871809 P29353-2 Reactome: R-HSA-354192 Reactome: R-HSA-381038 Reactome: R-HSA-512988 Reactome: R-HSA-5637810 Reactome: R-HSA-5654688 Reactome: R-HSA-5654699 Reactome: R-HSA-5654704 Reactome: R-HSA-5654719 Reactome: R-HSA-5673001 Reactome: R-HSA-74749 Reactome: R-HSA-74751 Reactome: R-HSA-8851805 P29353-2 Reactome: R-HSA-8853659 Reactome: R-HSA-8983432 Reactome: R-HSA-9009391 Reactome: R-HSA-9020558 Reactome: R-HSA-9026519 Reactome: R-HSA-9027284 Reactome: R-HSA-9034864 Reactome: R-HSA-912526 Reactome: R-HSA-9634285 Reactome: R-HSA-9634597 Reactome: R-HSA-9664565 Reactome: R-HSA-9665348 Reactome: R-HSA-9665686 Reactome: R-HSA-9674555 Reactome: R-HSA-9680350 Reactome: R-HSA-9725370
Cellular Localisation	Cytoplasm Cell Junction Focal Adhesion Isoform P46shc: Mitochondrion Matrix Localized To The Mitochondria Matrix Targeting Of Isoform P46shc To Mitochondria Is Mediated By Its First 32 Amino Acids Which Behave As A Bona Fide Mitochondrial Targeting Sequence Isoform P52shc And Isoform P66shc That Contain The Same Sequence But More Internally Located Display A Different Subcellular Localization Isoform P66shc: Mitochondrion In Case Of Oxidative Conditions Phosphorylation At 'Ser-36' Of Isoform P66shc Leads To Mitochondrial Accumulation
Alternative Antibody Names	Anti-Shc-Transforming Protein 1 antibody Anti-Shc-Transforming Protein 3 antibody Anti-Shc-Transforming Protein A antibody Anti-Src Homology 2 Domain-Containing-Transforming Protein C1 antibody Anti-Sh2 Domain Protein C1 antibody Anti-SHC1 antibody Anti-SHC antibody Anti-SHCA antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-SHC1 antibody (360-373) (STJ110036)