產品詳情
簡單介紹：
Anti-TFAP2C antibody (350-450) (STJ110050)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-TFAP2C (350-450) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TFAP2C |
| Gene ID: | 7022 |
| Uniprot ID: | AP2C_HUMAN |
| Immunogen Region: | 350-450 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human TFAP2C (NP_003213.1). |
| Immunogen Sequence: | NMLLAAQQLCKEFTELLSQD RTPHGTSRLAPVLETNIQNC LSHFSLITHGFGSQAICAAV SALQNYIKEALIVIDKSYMN PGDQSPADSNKTLEKMEKHR K |
| Post Translational Modifications | Sumoylated on Lys-10.which inhibits transcriptional activity. |
| Function | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. |
| Protein Name | Transcription Factor Ap-2 Gamma Ap2-Gamma Activating Enhancer-Binding Protein 2 Gamma Transcription Factor Erf-1 |
| Database Links | Reactome: R-HSA-3232118 Reactome: R-HSA-8866904 Reactome: R-HSA-8866906 Reactome: R-HSA-8866907 Reactome: R-HSA-8866910 Reactome: R-HSA-8866911 Reactome: R-HSA-9827857 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Ap-2 Gamma antibody Anti-Ap2-Gamma antibody Anti-Activating Enhancer-Binding Protein 2 Gamma antibody Anti-Transcription Factor Erf-1 antibody Anti-TFAP2C antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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