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Anti-TOP1 antibody (1-100) (STJ110052) STJ110052|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司
產品詳情

  • 產品名稱：Anti-TOP1 antibody (1-100) (STJ110052)

  • 產品型號：STJ110052
  • 產品廠商：ST john's laboratory
  • 產品文檔：
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簡單介紹：
Anti-TOP1 antibody (1-100) (STJ110052)
詳情介紹：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TOP1 (1-100) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TOP1
Gene ID: 7150
Uniprot ID: TOP1_HUMAN
Immunogen Region: 1-100
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DNA topoisomerase I (DNA topoisomerase I (TOP1) ) (NP_003277.1).
Immunogen Sequence: MSGDHLHNDSQIEADFRLND SHKHKDKHKDREHRHKEHKK EKDREKSKHSNSEHKDSEKK HKEKEKTKHKDGSSEKHKDK HKDRDKEKRKEEKVRASGDA
Tissue Specificity Endothelial cells.
Post Translational Modifications Sumoylated. Lys-117 is the main site of sumoylation. Sumoylation plays a role in partitioning TOP1 between nucleoli and nucleoplasm. Levels are dramatically increased on camptothecin (CPT) treatment. Phosphorylation at Ser-506 by CK2 increases binding to supercoiled DNA and sensitivity to camptothecin.
Function Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the BMAL1 promoter.
Protein Name Dna Topoisomerase 1
Dna Topoisomerase I
Database Links Reactome: R-HSA-4615885
Cellular Localisation Nucleus
Nucleolus
Nucleoplasm
Diffuse Nuclear Localization With Some Enrichment In Nucleoli
On Cpt Treatment
Cleared From Nucleoli Into Nucleoplasm
Sumoylated Forms Found In Both Nucleoplasm And Nucleoli
Alternative Antibody Names Anti-Dna Topoisomerase 1 antibody
Anti-Dna Topoisomerase I antibody
Anti-TOP1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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