產品詳情
簡單介紹：
Anti-FOS antibody [7D6-A9-D4] (STJ99211)
詳情介紹：
| Host: | Mouse |
| Applications: | WB |
| Reactivity: | Human/Rat/Monkey |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-Protein c-Fos is suitable for use in Western Blot research applications. |
| Clonality: | Monoclonal |
| Clone ID: | 7D6-A9-D4 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FOS |
| Gene ID: | 2353 |
| Uniprot ID: | FOS_HUMAN |
| Specificity: | This antibody detects endogenous levels of c-Fos and does not cross-react with related proteins. |
| Immunogen: | Purified recombinant human FOS protein fragments expressed in E.coli. |
| Function | Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. |
| Protein Name | Protein C-Fos Cellular Oncogene Fos Fos Proto-Oncogene - Ap-1 Transcription Factor Subunit G0/G1 Switch Regulatory Protein 7 Proto-Oncogene C-Fos Transcription Factor Ap-1 Subunit C-Fos |
| Database Links | Reactome: R-HSA-2559580 Reactome: R-HSA-2559582 Reactome: R-HSA-2871796 Reactome: R-HSA-450341 Reactome: R-HSA-6785807 Reactome: R-HSA-6796648 Reactome: R-HSA-9018519 Reactome: R-HSA-9031628 Reactome: R-HSA-9634638 Reactome: R-HSA-9768919 |
| Cellular Localisation | Nucleus Endoplasmic Reticulum Cytoplasm Cytosol In Quiescent Cells Present In Very Small Amounts In The Cytosol Following Induction Of Cell Growth First Localizes To The Endoplasmic Reticulum And Only Later To The Nucleus Localization At The Endoplasmic Reticulum Requires Dephosphorylation At Tyr-10 And Tyr-30 |
| Alternative Antibody Names | Anti-Protein C-Fos antibody Anti-Cellular Oncogene Fos antibody Anti-Fos Proto-Oncogene - Ap-1 Transcription Factor Subunit antibody Anti-G0/G1 Switch Regulatory Protein 7 antibody Anti-Proto-Oncogene C-Fos antibody Anti-Transcription Factor Ap-1 Subunit C-Fos antibody Anti-FOS antibody Anti-G0S7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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