Anti-Foxa2 antibody (1-100) [S1MR] (STJ11101591) STJ11101591|產品目錄|代理商|上海91麻豆福利视频网生物科技有限公司

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產品名稱：Anti-Foxa2 antibody (1-100) [S1MR] (STJ11101591)
產品型號：STJ11101591
產品廠商：ST john's laboratory
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Anti-Foxa2 antibody (1-100) [S1MR] (STJ11101591)

詳情介紹：

Host:	Rabbit
Applications:	WB/IF/IP
Reactivity:	Human/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-FOXA2 (1-100) is suitable for use in Western Blot, Immunofluorescence and Immunoprecipitation research applications.

Clonality:	Monoclonal
Clone ID:	S1MR
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IF/ICC 1:50-1:200 IP 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FOXA2
Gene ID:	3170
Uniprot ID:	FOXA2_HUMAN
Immunogen Region:	1-100
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HNF3 Beta/FOXA2 (Q9Y261).
Immunogen Sequence:	MLGAVKMEGHEPSDWSSYYA EPEGYSSVSNMNAGLGMNGM NTYMSMSAAAMGSGSGNMSA GSMNMSSYVGAGMSPSLAGM SPGAGAMAGMGGSAGAAGVA

Post Translational Modifications	Phosphorylation on Thr-156 abolishes binding to target promoters and subsequent transcription activation upon insulin stimulation.
Function	Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-ACAATTAGTTGTAGCTTCT-3'. In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs.FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
Protein Name	Hepatocyte Nuclear Factor 3-Beta Hnf-3-Beta Hnf-3b Forkhead Box Protein A2 Transcription Factor 3b Tcf-3b
Database Links	Reactome: R-HSA-210745 Reactome: R-HSA-9796292 Reactome: R-HSA-9823730
Cellular Localisation	Nucleus Cytoplasm Shuttles Between The Nucleus And Cytoplasm In A Crm1-Dependent Manner In Response To Insulin Signaling Via Akt1 Is Exported From The Nucleus
Alternative Antibody Names	Anti-Hepatocyte Nuclear Factor 3-Beta antibody Anti-Hnf-3-Beta antibody Anti-Hnf-3b antibody Anti-Forkhead Box Protein A2 antibody Anti-Transcription Factor 3b antibody Anti-Tcf-3b antibody Anti-FOXA2 antibody Anti-HNF3B antibody Anti-TCF3B antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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產品名稱：Anti-Foxa2 antibody (1-100) [S1MR] (STJ11101591)